TY - JOUR
T1 - Survival outcomes of obese patients in type II endometrial cancer
T2 - Defining the prognostic impact of increasing BMI
AU - Billingsley, Caroline C.
AU - Cansino, Catherine D
AU - O'Malley, David M.
AU - Cohn, David E.
AU - Fowler, Jeffrey M.
AU - Copeland, Larry J.
AU - Backes, Floor J.
AU - Salani, Ritu
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objective To investigate the role of obesity as a risk factor for type II endometrial cancer (EC), as well as the prognostic significance of increasing body mass index (BMI) on survival. Methods A single institution retrospective analysis of 154 type II EC cases from 1987 to 2010 was conducted. Patients were categorized into cohorts by BMI (normal (< 25), overweight (25-29.9), obese class I (30-34.9), and obese class II-III (≥ 35)). Descriptive, regression and ANOVA analyses were performed. Kaplan-Meier curves were compared with log rank tests. Results The BMI distribution was 22.8% normal BMI; 24% overweight; 17.5% class I; and 35.7% class II-III. The median follow up was 41 months. The median progression-free survival (PFS) was 45.4, 36.0, 35.3 and 42.0 months and overall survival (OS) was 54.7, 44.7, 44.8 and 49.7 months, among the respective groups. There was no association between BMI and PFS (p = 0.71), OS (p = 0.72), or time to recurrence (p = 0.71). There were no differences among the increasing BMI groups compared to normal weight women for the risk of death. Conclusions Our analysis did not reveal any differences in outcomes by BMI group. Our data reveals that obesity is highly prevalent in type II ECs, though obesity has not historically been described as a risk factor. While BMI as a single variable may not be prognostic for survival outcomes, the role of obesity as a risk factor for type II EC should be further investigated, given the increasing prevalence of obesity in type II ECs.
AB - Objective To investigate the role of obesity as a risk factor for type II endometrial cancer (EC), as well as the prognostic significance of increasing body mass index (BMI) on survival. Methods A single institution retrospective analysis of 154 type II EC cases from 1987 to 2010 was conducted. Patients were categorized into cohorts by BMI (normal (< 25), overweight (25-29.9), obese class I (30-34.9), and obese class II-III (≥ 35)). Descriptive, regression and ANOVA analyses were performed. Kaplan-Meier curves were compared with log rank tests. Results The BMI distribution was 22.8% normal BMI; 24% overweight; 17.5% class I; and 35.7% class II-III. The median follow up was 41 months. The median progression-free survival (PFS) was 45.4, 36.0, 35.3 and 42.0 months and overall survival (OS) was 54.7, 44.7, 44.8 and 49.7 months, among the respective groups. There was no association between BMI and PFS (p = 0.71), OS (p = 0.72), or time to recurrence (p = 0.71). There were no differences among the increasing BMI groups compared to normal weight women for the risk of death. Conclusions Our analysis did not reveal any differences in outcomes by BMI group. Our data reveals that obesity is highly prevalent in type II ECs, though obesity has not historically been described as a risk factor. While BMI as a single variable may not be prognostic for survival outcomes, the role of obesity as a risk factor for type II EC should be further investigated, given the increasing prevalence of obesity in type II ECs.
KW - Endometrial cancer
KW - Obesity
KW - Survival outcomes
KW - Type II
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U2 - 10.1016/j.ygyno.2016.01.020
DO - 10.1016/j.ygyno.2016.01.020
M3 - Article
C2 - 26801939
AN - SCOPUS:84959483794
VL - 140
SP - 405
EP - 408
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 3
ER -