TY - JOUR
T1 - Survival differences in women with serous tubal, ovarian, peritoneal, and uterine carcinomas
AU - Usach, Irina
AU - Blansit, Kevin
AU - Chen, Lee May
AU - Ueda, Stefanie
AU - Brooks, Rebecca
AU - Kapp, Daniel S.
AU - Chan, John K.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Objective The fallopian tube has been implicated as the primary origin of pelvic serous cancers. We proposed to determine the survival outcomes of serous tubal, ovarian, peritoneal, and uterine cancer patients. Study Design Data were obtained from the National Cancer Institute between 2004 and 2009. Kaplan-Meier and Cox proportional hazards models were used for analysis. Results Of 12,336 high-grade serous cancer patients, 563 were tubal (TC), 8560 ovarian (OC), 1037 primary peritoneal (PPC), and 2176 uterine cancer (USC). The median ages of these patients were 63 vs 62 vs 67 vs 68 years, respectively. The majority were white (89% vs 88% vs 91% vs 74%). The overall 5 year, disease-specific survival was 37%. The survivals of those with TC, OC, PPC, and USC were 50%, 37%, 26%, and 40% (P <.01). There was no detailed staging on PPC cancers. Adjusted for stage, the survival of those with stage I, II, III, and IV TC were 73%, 62%, 44%, and 22% (P <.01), OC were 83%, 64%, 34%, and 15% (P <.01), and USC were 88%, 72%, 55%, and 17% (P <.01). On multivariate analysis, younger age, white race, earlier stage, and tubal origin were independent predictors for improved survival. Conclusion In advanced-staged serous cancer patients, tubal cancer patients have better survivals compared with ovarian, peritoneal, and uterine cancer.
AB - Objective The fallopian tube has been implicated as the primary origin of pelvic serous cancers. We proposed to determine the survival outcomes of serous tubal, ovarian, peritoneal, and uterine cancer patients. Study Design Data were obtained from the National Cancer Institute between 2004 and 2009. Kaplan-Meier and Cox proportional hazards models were used for analysis. Results Of 12,336 high-grade serous cancer patients, 563 were tubal (TC), 8560 ovarian (OC), 1037 primary peritoneal (PPC), and 2176 uterine cancer (USC). The median ages of these patients were 63 vs 62 vs 67 vs 68 years, respectively. The majority were white (89% vs 88% vs 91% vs 74%). The overall 5 year, disease-specific survival was 37%. The survivals of those with TC, OC, PPC, and USC were 50%, 37%, 26%, and 40% (P <.01). There was no detailed staging on PPC cancers. Adjusted for stage, the survival of those with stage I, II, III, and IV TC were 73%, 62%, 44%, and 22% (P <.01), OC were 83%, 64%, 34%, and 15% (P <.01), and USC were 88%, 72%, 55%, and 17% (P <.01). On multivariate analysis, younger age, white race, earlier stage, and tubal origin were independent predictors for improved survival. Conclusion In advanced-staged serous cancer patients, tubal cancer patients have better survivals compared with ovarian, peritoneal, and uterine cancer.
KW - cancer origin
KW - endometrial cancer
KW - ovarian cancer
KW - serous cancer
KW - survival analysis
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U2 - 10.1016/j.ajog.2014.08.016
DO - 10.1016/j.ajog.2014.08.016
M3 - Article
C2 - 25149685
AN - SCOPUS:84921652072
VL - 212
SP - 188.e1-188.e6
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -