Abstract
Thymic disease is uncommon, but when encountered, surgery is most often the treatment of choice. The thymus is located in the cranial mediastinum in a cranioventral location. Thymic pathology is most often noted incidentally in dogs and cats during routine geriatric thoracic radiographic screening. Because of the location of the thymus in the cranial mediastinum and its relative proximity to the respiratory tract, clinical signs seen with thymic disease include dyspnea, coughing, and dysphonia. The most commonly described paraneoplastic syndrome that occurs in conjunction with thymoma is myasthenia gravis. Myasthenia gravis occurs when acetylcholine receptors are targeted by autoantibodies. Myasthenia gravis can also result in megaesophagus, which can cause regurgitation; this likely occurs due to dysfunction of the striated muscle of the canine esophagus. A cystic thymus has been reported in two other feline cases: one in conjunction with myasthenia gravis and one associated with thymic hyperplasia.
| Original language | English (US) |
|---|---|
| Title of host publication | Small Animal Soft Tissue Surgery |
| Publisher | Wiley Blackwell |
| Pages | 72-81 |
| Number of pages | 10 |
| ISBN (Print) | 9781118997505, 9780813807829 |
| DOIs | |
| State | Published - Jan 4 2013 |
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Keywords
- Canine esophagus
- Cranial mediastinum
- Feline
- Surgical treatment
- Thymic disease
ASJC Scopus subject areas
- veterinary(all)
Cite this
Surgical Treatment of Thymic Disease. / Culp, William T.
Small Animal Soft Tissue Surgery. Wiley Blackwell, 2013. p. 72-81.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Surgical Treatment of Thymic Disease
AU - Culp, William T
PY - 2013/1/4
Y1 - 2013/1/4
N2 - Thymic disease is uncommon, but when encountered, surgery is most often the treatment of choice. The thymus is located in the cranial mediastinum in a cranioventral location. Thymic pathology is most often noted incidentally in dogs and cats during routine geriatric thoracic radiographic screening. Because of the location of the thymus in the cranial mediastinum and its relative proximity to the respiratory tract, clinical signs seen with thymic disease include dyspnea, coughing, and dysphonia. The most commonly described paraneoplastic syndrome that occurs in conjunction with thymoma is myasthenia gravis. Myasthenia gravis occurs when acetylcholine receptors are targeted by autoantibodies. Myasthenia gravis can also result in megaesophagus, which can cause regurgitation; this likely occurs due to dysfunction of the striated muscle of the canine esophagus. A cystic thymus has been reported in two other feline cases: one in conjunction with myasthenia gravis and one associated with thymic hyperplasia.
AB - Thymic disease is uncommon, but when encountered, surgery is most often the treatment of choice. The thymus is located in the cranial mediastinum in a cranioventral location. Thymic pathology is most often noted incidentally in dogs and cats during routine geriatric thoracic radiographic screening. Because of the location of the thymus in the cranial mediastinum and its relative proximity to the respiratory tract, clinical signs seen with thymic disease include dyspnea, coughing, and dysphonia. The most commonly described paraneoplastic syndrome that occurs in conjunction with thymoma is myasthenia gravis. Myasthenia gravis occurs when acetylcholine receptors are targeted by autoantibodies. Myasthenia gravis can also result in megaesophagus, which can cause regurgitation; this likely occurs due to dysfunction of the striated muscle of the canine esophagus. A cystic thymus has been reported in two other feline cases: one in conjunction with myasthenia gravis and one associated with thymic hyperplasia.
KW - Canine esophagus
KW - Cranial mediastinum
KW - Feline
KW - Surgical treatment
KW - Thymic disease
UR - http://www.scopus.com/inward/record.url?scp=84926212488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926212488&partnerID=8YFLogxK
U2 - 10.1002/9781118997505.ch7
DO - 10.1002/9781118997505.ch7
M3 - Chapter
AN - SCOPUS:84926212488
SN - 9781118997505
SN - 9780813807829
SP - 72
EP - 81
BT - Small Animal Soft Tissue Surgery
PB - Wiley Blackwell
ER -