Surgical treatment of patients with single and dual pathology: Relevance of lesion and of hippocampal atrophy to seizure outcome

L. M. Li, F. Cendes, Craig Watson, Frederick Andermann, D. R. Fish, F. Dubeau, S. Free, A. Olivier, W. Harkness, D. G T Thomas, J. S. Duncan, J. W A S Sander, S. D. Shorvon, M. J. Cook, D. L. Arnold

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Modern neuroimaging can disclose epileptogenic lesions in many patients with partial epilepsy and, at times, display the coexistence of hippocampal atrophy in addition to an extrahippocampal lesion (dual pathology). We studied the postoperative seizure outcome of 64 patients with lesional epilepsy (median follow-up, 30 months) and considered separately the surgical results in the 51 patients with a single lesion and in the 13 who had dual pathology. In patients with a single lesion, 85% were seizure free or significantly improved (Engel's class I-II) when the lesion was totally removed compared with only 40% when there was incomplete resection (p < 0.007). All three patients with dual pathology who had both the lesion and the atrophic hippocampus removed became seizure free. In contrast, only 2 of the 10 patients with dual pathology undergoing surgery aimed at the lesion or at the hippocampus alone became seizure free (p < 0.05), although 4 of them showed significant improvement (Engel's class II). We conclude that the outcome in patients with single epileptogenic lesions is usually dependent upon the completeness of lesion resection. In patients with dual pathology, surgery should, if possible, include resection of both the lesion and the atrophic hippocampus.

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalNeurology
Volume48
Issue number2
StatePublished - Feb 1997
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Li, L. M., Cendes, F., Watson, C., Andermann, F., Fish, D. R., Dubeau, F., Free, S., Olivier, A., Harkness, W., Thomas, D. G. T., Duncan, J. S., Sander, J. W. A. S., Shorvon, S. D., Cook, M. J., & Arnold, D. L. (1997). Surgical treatment of patients with single and dual pathology: Relevance of lesion and of hippocampal atrophy to seizure outcome. Neurology, 48(2), 437-444.