Surgical outcome in patients with epilepsy and dual pathology

L. M. Li, F. Cendes, Frederick Andermann, Craig Watson, D. R. Fish, M. J. Cook, F. Dubeau, J. S. Duncan, S. D. Shorvon, S. F. Berkovic, S. Free, A. Olivier, W. Harkness, D. L. Arnold

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

High-resolution MRI can detect dual pathology (an extrahippocampal lesion plus hippocampal atrophy) in about 5-20% of patients with refractory partial epilepsy referred for surgical evaluation. We report the results of 41 surgical interventions in 38 adults (mean age 31 years, range 14-63 years) with dual pathology. Three patients had two operations. The mean postoperative follow-up was 37 months (range 12-180 months). The extrahippocampal lesions were cortical dysgenesis in 15, tumour in 10, contusion/infarct in eight and vascular malformation in five patients. The surgical approach aimed to remove what was considered to be the most epileptogenic lesion, and the 41 operations were classified into lesionectomy (removal of an extrahippocampal lesion); mesial temporal resection (removal of an atrophic hippocampus); and lesionectomy plus mesial temporal resection (removal of both the lesion and the atrophic hippocampus). Lesionectomy plus mesial temporal resection resulted in complete freedom from seizures in 11/15 (73%) patients, while only 2/10 (20%) patients who had mesial temporal resection alone and 2/16 (12.5%) who had a lesionectomy alone were seizure-free (P < 0.001). When classes I and II were considered together results improved to 86, 30 and 31%, respectively. Our findings indicate that in patients with dual pathology removal of both the lesion and the atrophic hippocampus is the best surgical approach and should be considered whenever possible.

Original languageEnglish (US)
Pages (from-to)799-805
Number of pages7
JournalBrain
Volume122
Issue number5
DOIs
StatePublished - May 1999
Externally publishedYes

Fingerprint

Epilepsy
Pathology
Hippocampus
Seizures
Vascular Malformations
Partial Epilepsy
Contusions
Atrophy
Neoplasms

Keywords

  • Dual pathology
  • Epilepsy
  • Hippocampal sclerosis
  • Outcome
  • Surgery

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Li, L. M., Cendes, F., Andermann, F., Watson, C., Fish, D. R., Cook, M. J., ... Arnold, D. L. (1999). Surgical outcome in patients with epilepsy and dual pathology. Brain, 122(5), 799-805. https://doi.org/10.1093/brain/122.5.799

Surgical outcome in patients with epilepsy and dual pathology. / Li, L. M.; Cendes, F.; Andermann, Frederick; Watson, Craig; Fish, D. R.; Cook, M. J.; Dubeau, F.; Duncan, J. S.; Shorvon, S. D.; Berkovic, S. F.; Free, S.; Olivier, A.; Harkness, W.; Arnold, D. L.

In: Brain, Vol. 122, No. 5, 05.1999, p. 799-805.

Research output: Contribution to journalArticle

Li, LM, Cendes, F, Andermann, F, Watson, C, Fish, DR, Cook, MJ, Dubeau, F, Duncan, JS, Shorvon, SD, Berkovic, SF, Free, S, Olivier, A, Harkness, W & Arnold, DL 1999, 'Surgical outcome in patients with epilepsy and dual pathology', Brain, vol. 122, no. 5, pp. 799-805. https://doi.org/10.1093/brain/122.5.799
Li LM, Cendes F, Andermann F, Watson C, Fish DR, Cook MJ et al. Surgical outcome in patients with epilepsy and dual pathology. Brain. 1999 May;122(5):799-805. https://doi.org/10.1093/brain/122.5.799
Li, L. M. ; Cendes, F. ; Andermann, Frederick ; Watson, Craig ; Fish, D. R. ; Cook, M. J. ; Dubeau, F. ; Duncan, J. S. ; Shorvon, S. D. ; Berkovic, S. F. ; Free, S. ; Olivier, A. ; Harkness, W. ; Arnold, D. L. / Surgical outcome in patients with epilepsy and dual pathology. In: Brain. 1999 ; Vol. 122, No. 5. pp. 799-805.
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