Surgical Management of Neurofibromatosis

Colin M. Parsons, Robert J Canter, Vijay P Khatri

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Neurofibromatoses are a complex set of genetic diseases with a wide spectrum of clinical manifestations. Life-threatening complications may develop as the result of tumor progression. Surgical intervention is the only effective means of treatment for progressive pain, disfigurement, functional compromise, and malignancy. In the future, molecular advances should allow for the development of targeted therapies to treat patients who have neurofibromatosis in addition to those who have sporadic tumors. Tumor profiling should allow us to guide therapies and predict responses.

Original languageEnglish (US)
Pages (from-to)175-196
Number of pages22
JournalSurgical Oncology Clinics of North America
Volume18
Issue number1
DOIs
StatePublished - Jan 2009

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Keywords

  • Genetics
  • Malignant peripheral nerve sheath tumor
  • Neurofibromatosis
  • Schwannoma

ASJC Scopus subject areas

  • Oncology
  • Surgery

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