Surgical and tissue engineering strategies for articular cartilage and meniscus repair

Heenam Kwon, Wendy E. Brown, Cassandra A Lee, Dean Wang, Nikolaos Paschos, Jerry C. Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalReview article

Abstract

Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately results in arthritis. Different forms of arthritis affect ~50 million people in the USA alone, and it is therefore crucial to identify methods that will halt or slow the progression to arthritis, starting with the initiating events of cartilage and meniscus defects. The surgical approaches in current use have a limited capacity for tissue regeneration and yield only short-term relief of symptoms. Tissue engineering approaches are emerging as alternatives to current surgical methods for cartilage and meniscus repair. Several cell-based and tissue-engineered products are currently in clinical trials for cartilage lesions and meniscal tears, opening new avenues for cartilage and meniscus regeneration. This Review provides a summary of surgical techniques, including tissue-engineered products, that are currently in clinical use, as well as a discussion of state-of-the-art tissue engineering strategies and technologies that are being developed for use in articular cartilage and meniscus repair and regeneration. The obstacles to clinical translation of these strategies are also included to inform the development of innovative tissue engineering approaches.

Original languageEnglish (US)
JournalNature Reviews Rheumatology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Articular Cartilage
Tissue Engineering
Cartilage
Arthritis
Regeneration
Tears
Meniscus
Clinical Trials
Technology
Wounds and Injuries

ASJC Scopus subject areas

  • Rheumatology

Cite this

Surgical and tissue engineering strategies for articular cartilage and meniscus repair. / Kwon, Heenam; Brown, Wendy E.; Lee, Cassandra A; Wang, Dean; Paschos, Nikolaos; Hu, Jerry C.; Athanasiou, Kyriacos A.

In: Nature Reviews Rheumatology, 01.01.2019.

Research output: Contribution to journalReview article

Kwon, Heenam ; Brown, Wendy E. ; Lee, Cassandra A ; Wang, Dean ; Paschos, Nikolaos ; Hu, Jerry C. ; Athanasiou, Kyriacos A. / Surgical and tissue engineering strategies for articular cartilage and meniscus repair. In: Nature Reviews Rheumatology. 2019.
@article{63c82685b8a74945bef3cf4394b93b60,
title = "Surgical and tissue engineering strategies for articular cartilage and meniscus repair",
abstract = "Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately results in arthritis. Different forms of arthritis affect ~50 million people in the USA alone, and it is therefore crucial to identify methods that will halt or slow the progression to arthritis, starting with the initiating events of cartilage and meniscus defects. The surgical approaches in current use have a limited capacity for tissue regeneration and yield only short-term relief of symptoms. Tissue engineering approaches are emerging as alternatives to current surgical methods for cartilage and meniscus repair. Several cell-based and tissue-engineered products are currently in clinical trials for cartilage lesions and meniscal tears, opening new avenues for cartilage and meniscus regeneration. This Review provides a summary of surgical techniques, including tissue-engineered products, that are currently in clinical use, as well as a discussion of state-of-the-art tissue engineering strategies and technologies that are being developed for use in articular cartilage and meniscus repair and regeneration. The obstacles to clinical translation of these strategies are also included to inform the development of innovative tissue engineering approaches.",
author = "Heenam Kwon and Brown, {Wendy E.} and Lee, {Cassandra A} and Dean Wang and Nikolaos Paschos and Hu, {Jerry C.} and Athanasiou, {Kyriacos A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1038/s41584-019-0255-1",
language = "English (US)",
journal = "Nature reviews. Rheumatology",
issn = "1759-4790",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Surgical and tissue engineering strategies for articular cartilage and meniscus repair

AU - Kwon, Heenam

AU - Brown, Wendy E.

AU - Lee, Cassandra A

AU - Wang, Dean

AU - Paschos, Nikolaos

AU - Hu, Jerry C.

AU - Athanasiou, Kyriacos A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately results in arthritis. Different forms of arthritis affect ~50 million people in the USA alone, and it is therefore crucial to identify methods that will halt or slow the progression to arthritis, starting with the initiating events of cartilage and meniscus defects. The surgical approaches in current use have a limited capacity for tissue regeneration and yield only short-term relief of symptoms. Tissue engineering approaches are emerging as alternatives to current surgical methods for cartilage and meniscus repair. Several cell-based and tissue-engineered products are currently in clinical trials for cartilage lesions and meniscal tears, opening new avenues for cartilage and meniscus regeneration. This Review provides a summary of surgical techniques, including tissue-engineered products, that are currently in clinical use, as well as a discussion of state-of-the-art tissue engineering strategies and technologies that are being developed for use in articular cartilage and meniscus repair and regeneration. The obstacles to clinical translation of these strategies are also included to inform the development of innovative tissue engineering approaches.

AB - Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately results in arthritis. Different forms of arthritis affect ~50 million people in the USA alone, and it is therefore crucial to identify methods that will halt or slow the progression to arthritis, starting with the initiating events of cartilage and meniscus defects. The surgical approaches in current use have a limited capacity for tissue regeneration and yield only short-term relief of symptoms. Tissue engineering approaches are emerging as alternatives to current surgical methods for cartilage and meniscus repair. Several cell-based and tissue-engineered products are currently in clinical trials for cartilage lesions and meniscal tears, opening new avenues for cartilage and meniscus regeneration. This Review provides a summary of surgical techniques, including tissue-engineered products, that are currently in clinical use, as well as a discussion of state-of-the-art tissue engineering strategies and technologies that are being developed for use in articular cartilage and meniscus repair and regeneration. The obstacles to clinical translation of these strategies are also included to inform the development of innovative tissue engineering approaches.

UR - http://www.scopus.com/inward/record.url?scp=85068901705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068901705&partnerID=8YFLogxK

U2 - 10.1038/s41584-019-0255-1

DO - 10.1038/s41584-019-0255-1

M3 - Review article

JO - Nature reviews. Rheumatology

JF - Nature reviews. Rheumatology

SN - 1759-4790

ER -