Surface modification with alginate-derived polymers for stable, protein-repellent, long-circulating gold nanoparticles

Anu Kodiyan, Eduardo Silva, Jaeyun Kim, Michael Aizenberg, David J. Mooney

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Figure Persented: Poly(ethylene) glycol is commonly used to stabilize gold nanoparticles (GNPs). In this study, we evaluated the ability of cysteine-functionalized alginate-derived polymers to both provide colloidal stability to GNPs and avoid recognition and sequestration by the body's defense system. These polymers contain multiple reactive chemical groups (hydroxyl and carboxyl groups) that could allow for ready functionalization with, for example, cell-targeting ligands and therapeutic drugs. We report here that alginate-coupled GNPs demonstrate enhanced stability in comparison with bare citrate-coated GNPs and a similar lack of interaction with proteins in vitro and long in vivo circulation as PEG-coated GNPs.

Original languageEnglish (US)
Pages (from-to)4796-4805
Number of pages10
JournalACS Nano
Volume6
Issue number6
DOIs
StatePublished - Jun 26 2012

Keywords

  • cellular uptake
  • G-block
  • PEG
  • pharmacokinetics
  • protein repellence
  • thiol polymers

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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