Surface modification using cubic silsesquioxane ligands. facile synthesis of water-soluble metal oxide nanoparticles

Benjamin L. Frankamp, Nicholas O Fischer, Rui Hong, Sudhanshu Srivastava, Vincent M. Rotello

Research output: Contribution to journalArticle

53 Scopus citations


The use of magnetic nanoparticles in biological applications is hampered by the lack of versatile methods to transfer them into aqueous solutions. Monolayer exchange using anionic octa(tetramethylammonium)-polyhedral oligomeric silsesquioxane provides individual particles that are soluble in aqueous environments and possess excellent stability in biologically relevant pH ranges and salt concentrations. In addition, this surface exchange reaction proved to be general in nature, allowing facile functionalization of a variety of magnetic nanoparticles.

Original languageEnglish (US)
Pages (from-to)956-959
Number of pages4
JournalChemistry of Materials
Issue number4
Publication statusPublished - Feb 21 2006
Externally publishedYes


ASJC Scopus subject areas

  • Materials Chemistry
  • Materials Science(all)

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