Surface-energy dependent spreading of lipid monolayers and bilayers

Babak Sanii, Atul N. Parikh

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Spontaneous spreading of phospholipids following hydration by water is directly compared on hydrophilic and hydrophobic surfaces using planar, composite substrates exhibiting binary patterns of surface energies. The use of patterned substrates - in conjunction with real-time, quantitative applications of imaging ellipsometry and epifluorescence microscopy - affords a side-by-side comparison of spreading kinetics and equilibrium morphologies following the hydration of a single parent-lipid source. We find that for fluid phospholipids (T > Tm), substantially contiguous bimolecular and mono-molecular lipid layers spread away from a source on hydrophilic and hydrophobic surfaces, respectively. For bilayers and monolayers, the advancing lipid sheets exhibit square-root-of-time dependent kinetics reflecting a balance between a spreading force and a resistive drag. Furthermore, monolayers advance at only a slightly faster rate (by a factor of 1.7 ± 0.2) than bilayers despite a substantially higher available spreading energy. This apparently counter-intuitive observation can be reconciled in terms of a corresponding rise in the competing drag energy - consistent with the differences in slip-planes associated with mono- and bilayer spreading. This journal is

Original languageEnglish (US)
Pages (from-to)974-977
Number of pages4
JournalSoft Matter
Volume3
Issue number8
DOIs
StatePublished - 2007

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Interfacial energy
surface energy
lipids
Monolayers
Lipids
Hydration
Drag
Phospholipids
Kinetics
Ellipsometry
drag
Substrates
hydration
Microscopic examination
Imaging techniques
kinetics
Fluids
Water
Composite materials
ellipsometry

ASJC Scopus subject areas

  • Chemistry (miscellaneous)

Cite this

Surface-energy dependent spreading of lipid monolayers and bilayers. / Sanii, Babak; Parikh, Atul N.

In: Soft Matter, Vol. 3, No. 8, 2007, p. 974-977.

Research output: Contribution to journalArticle

Sanii, Babak ; Parikh, Atul N. / Surface-energy dependent spreading of lipid monolayers and bilayers. In: Soft Matter. 2007 ; Vol. 3, No. 8. pp. 974-977.
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