Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome

Zsolt Balogh, Bruce A. McKinley, Christine S Cocanour, Rosemary A. Kozar, Alicia Valdivia, R. Matthew Sailors, Frederick A. Moore, Donald E. Fry, Steven Stain, Gregory Jurkovich

Research output: Contribution to journalArticle

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Abstract

Hypothesis: Normal resuscitation (oxygen delivery index [DO2I] ≥500 mL/min per square meter), compared with supranormal trauma resuscitation (DO2I ≥600 mL/min per square meter), requires less crystalloid volume, thus decreasing the incidence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Design: Retrospective analysis of a prospective database. Setting: Twenty-bed intensive care unit (ICU) in a regional level I trauma center. Patients: Patients with major trauma (injury severity score > 15, initial base deficit ≥6 mEq/L, or need for ≥6 units of packed red blood cells in the first 12 hours) or age 65 years or older with any 2 of the previous criteria. Interventions: Shock/trauma resuscitation protocol: pulmonary artery catheter, gastric tonometry, urinary bladder pressure measurements, lactated Ringer infusion, packed red blood cell transfusion, and moderate inotrope support, as needed, in that sequence, to attain and maintain a DO2I greater than or equal to 600 mL/min per m2 (16 months, ending January 1, 2001, n = 85) or a DO2I greater than or equal to 500 mL/min per square meter (16 months, starting January 1, 2001, n = 71) for the first 24 hours in the ICU. Main Outcome Measures: Lactated Ringer infusion volume (liters) at ICU admission, gastric partial carbon dioxide minus end-tidal carbon dioxide (GAPCO2), IAH (urinary bladder pressure measurements >20 mm Hg), ACS (urinary bladder pressure measurements >25 mm Hg with organ dysfunction), multiple organ failure, and mortality. Results: Demographics, injury severity, and shock severity parameters were similar in both groups. The supranormal resuscitation group required more lactated Ringer infusion volume in the first 24 hours in the ICU (mean ± SD, 13 ± 2 vs 7 ± 1 L; P<.05) and had higher GAPCO2 (16 ± 2 vs 7 ± 1 mm Hg; P<.05). In the supranormal group, IAH (42% vs 20%; P<.05) and ACS (16% vs 8%; P<.05) were more frequent. The conventional trauma outcomes, such as multiple organ failure (22% vs 9%; P<.05) and mortality (27% vs 11%; P<.05) were less favorable in the supranormal resuscitation group. Conclusion: Supranormal resuscitation, compared with normal resuscitation, was associated with more lactated Ringer infusion, decreased intestinal perfusion (higher GAPCO2), and an increased incidence of IAH, ACS, multiple organ failure, and death.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalArchives of Surgery
Volume138
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Intra-Abdominal Hypertension
Resuscitation
Wounds and Injuries
Intensive Care Units
Multiple Organ Failure
Urinary Bladder
Pressure
Carbon Dioxide
Shock
Stomach
Erythrocyte Transfusion
Injury Severity Score
Mortality
Trauma Centers
Incidence
Manometry
Pulmonary Artery
Catheters
Perfusion
Erythrocytes

ASJC Scopus subject areas

  • Surgery

Cite this

Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. / Balogh, Zsolt; McKinley, Bruce A.; Cocanour, Christine S; Kozar, Rosemary A.; Valdivia, Alicia; Sailors, R. Matthew; Moore, Frederick A.; Fry, Donald E.; Stain, Steven; Jurkovich, Gregory.

In: Archives of Surgery, Vol. 138, No. 6, 01.06.2003, p. 637-643.

Research output: Contribution to journalArticle

Balogh, Z, McKinley, BA, Cocanour, CS, Kozar, RA, Valdivia, A, Sailors, RM, Moore, FA, Fry, DE, Stain, S & Jurkovich, G 2003, 'Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome', Archives of Surgery, vol. 138, no. 6, pp. 637-643. https://doi.org/10.1001/archsurg.138.6.637
Balogh, Zsolt ; McKinley, Bruce A. ; Cocanour, Christine S ; Kozar, Rosemary A. ; Valdivia, Alicia ; Sailors, R. Matthew ; Moore, Frederick A. ; Fry, Donald E. ; Stain, Steven ; Jurkovich, Gregory. / Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. In: Archives of Surgery. 2003 ; Vol. 138, No. 6. pp. 637-643.
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T1 - Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome

AU - Balogh, Zsolt

AU - McKinley, Bruce A.

AU - Cocanour, Christine S

AU - Kozar, Rosemary A.

AU - Valdivia, Alicia

AU - Sailors, R. Matthew

AU - Moore, Frederick A.

AU - Fry, Donald E.

AU - Stain, Steven

AU - Jurkovich, Gregory

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Hypothesis: Normal resuscitation (oxygen delivery index [DO2I] ≥500 mL/min per square meter), compared with supranormal trauma resuscitation (DO2I ≥600 mL/min per square meter), requires less crystalloid volume, thus decreasing the incidence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Design: Retrospective analysis of a prospective database. Setting: Twenty-bed intensive care unit (ICU) in a regional level I trauma center. Patients: Patients with major trauma (injury severity score > 15, initial base deficit ≥6 mEq/L, or need for ≥6 units of packed red blood cells in the first 12 hours) or age 65 years or older with any 2 of the previous criteria. Interventions: Shock/trauma resuscitation protocol: pulmonary artery catheter, gastric tonometry, urinary bladder pressure measurements, lactated Ringer infusion, packed red blood cell transfusion, and moderate inotrope support, as needed, in that sequence, to attain and maintain a DO2I greater than or equal to 600 mL/min per m2 (16 months, ending January 1, 2001, n = 85) or a DO2I greater than or equal to 500 mL/min per square meter (16 months, starting January 1, 2001, n = 71) for the first 24 hours in the ICU. Main Outcome Measures: Lactated Ringer infusion volume (liters) at ICU admission, gastric partial carbon dioxide minus end-tidal carbon dioxide (GAPCO2), IAH (urinary bladder pressure measurements >20 mm Hg), ACS (urinary bladder pressure measurements >25 mm Hg with organ dysfunction), multiple organ failure, and mortality. Results: Demographics, injury severity, and shock severity parameters were similar in both groups. The supranormal resuscitation group required more lactated Ringer infusion volume in the first 24 hours in the ICU (mean ± SD, 13 ± 2 vs 7 ± 1 L; P<.05) and had higher GAPCO2 (16 ± 2 vs 7 ± 1 mm Hg; P<.05). In the supranormal group, IAH (42% vs 20%; P<.05) and ACS (16% vs 8%; P<.05) were more frequent. The conventional trauma outcomes, such as multiple organ failure (22% vs 9%; P<.05) and mortality (27% vs 11%; P<.05) were less favorable in the supranormal resuscitation group. Conclusion: Supranormal resuscitation, compared with normal resuscitation, was associated with more lactated Ringer infusion, decreased intestinal perfusion (higher GAPCO2), and an increased incidence of IAH, ACS, multiple organ failure, and death.

AB - Hypothesis: Normal resuscitation (oxygen delivery index [DO2I] ≥500 mL/min per square meter), compared with supranormal trauma resuscitation (DO2I ≥600 mL/min per square meter), requires less crystalloid volume, thus decreasing the incidence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Design: Retrospective analysis of a prospective database. Setting: Twenty-bed intensive care unit (ICU) in a regional level I trauma center. Patients: Patients with major trauma (injury severity score > 15, initial base deficit ≥6 mEq/L, or need for ≥6 units of packed red blood cells in the first 12 hours) or age 65 years or older with any 2 of the previous criteria. Interventions: Shock/trauma resuscitation protocol: pulmonary artery catheter, gastric tonometry, urinary bladder pressure measurements, lactated Ringer infusion, packed red blood cell transfusion, and moderate inotrope support, as needed, in that sequence, to attain and maintain a DO2I greater than or equal to 600 mL/min per m2 (16 months, ending January 1, 2001, n = 85) or a DO2I greater than or equal to 500 mL/min per square meter (16 months, starting January 1, 2001, n = 71) for the first 24 hours in the ICU. Main Outcome Measures: Lactated Ringer infusion volume (liters) at ICU admission, gastric partial carbon dioxide minus end-tidal carbon dioxide (GAPCO2), IAH (urinary bladder pressure measurements >20 mm Hg), ACS (urinary bladder pressure measurements >25 mm Hg with organ dysfunction), multiple organ failure, and mortality. Results: Demographics, injury severity, and shock severity parameters were similar in both groups. The supranormal resuscitation group required more lactated Ringer infusion volume in the first 24 hours in the ICU (mean ± SD, 13 ± 2 vs 7 ± 1 L; P<.05) and had higher GAPCO2 (16 ± 2 vs 7 ± 1 mm Hg; P<.05). In the supranormal group, IAH (42% vs 20%; P<.05) and ACS (16% vs 8%; P<.05) were more frequent. The conventional trauma outcomes, such as multiple organ failure (22% vs 9%; P<.05) and mortality (27% vs 11%; P<.05) were less favorable in the supranormal resuscitation group. Conclusion: Supranormal resuscitation, compared with normal resuscitation, was associated with more lactated Ringer infusion, decreased intestinal perfusion (higher GAPCO2), and an increased incidence of IAH, ACS, multiple organ failure, and death.

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