Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus

S. A. Hoffman, D. W. Shucard, Hilary A Brodie, C. Reifenrath, R. J. Harbeck

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalJournal of Neuroimmunology
Volume2
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Antigen-Antibody Complex
Body Temperature
Systemic Lupus Erythematosus
Hypothalamus
Drinking
Central Nervous System
Antigens
Antibodies

Keywords

  • Body temperature
  • Hypothalamus
  • Immune complex formation
  • Rat
  • Systemic lupus erythematosus
  • Water consumption

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus. / Hoffman, S. A.; Shucard, D. W.; Brodie, Hilary A; Reifenrath, C.; Harbeck, R. J.

In: Journal of Neuroimmunology, Vol. 2, No. 2, 1982, p. 167-176.

Research output: Contribution to journalArticle

@article{fa40ee1ab34a482791c16ede3e6d5f74,
title = "Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus",
abstract = "Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.",
keywords = "Body temperature, Hypothalamus, Immune complex formation, Rat, Systemic lupus erythematosus, Water consumption",
author = "Hoffman, {S. A.} and Shucard, {D. W.} and Brodie, {Hilary A} and C. Reifenrath and Harbeck, {R. J.}",
year = "1982",
doi = "10.1016/0165-5728(82)90007-8",
language = "English (US)",
volume = "2",
pages = "167--176",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus

AU - Hoffman, S. A.

AU - Shucard, D. W.

AU - Brodie, Hilary A

AU - Reifenrath, C.

AU - Harbeck, R. J.

PY - 1982

Y1 - 1982

N2 - Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.

AB - Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.

KW - Body temperature

KW - Hypothalamus

KW - Immune complex formation

KW - Rat

KW - Systemic lupus erythematosus

KW - Water consumption

UR - http://www.scopus.com/inward/record.url?scp=0019992964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019992964&partnerID=8YFLogxK

U2 - 10.1016/0165-5728(82)90007-8

DO - 10.1016/0165-5728(82)90007-8

M3 - Article

VL - 2

SP - 167

EP - 176

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 2

ER -