Suppression of water intake by immune complex formation in the hypothalamus. Implications for Systemic Lupus Erythematosus

S. A. Hoffman, D. W. Shucard, Hilary A Brodie, C. Reifenrath, R. J. Harbeck

Research output: Contribution to journalArticle

12 Scopus citations


Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions with the central nervous system can alter behavior.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalJournal of Neuroimmunology
Issue number2
StatePublished - 1982
Externally publishedYes



  • Body temperature
  • Hypothalamus
  • Immune complex formation
  • Rat
  • Systemic lupus erythematosus
  • Water consumption

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this