Suppression of sialylated by sulfated oligosaccharides in negative MALDI-FTMS

Hyun Joo An, Carlito B Lebrilla

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Sialylated oligosaccharides are suppressed by sulfated oligosaccharides during matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The sialylated oligosaccharide may be suppressed by as much as a factor of ten to twenty. This suppression factor is constant over a large concentration range. As both sialylated and sulfated (or anionic) oligosaccharides are found together in many biological systems, the suppression has important consequences in the analysis of these compounds. Methods for overcoming the effect of suppression without laborious separation are provided.

Original languageEnglish (US)
Pages (from-to)117-127
Number of pages11
JournalIsrael Journal of Chemistry
Issue number2
StatePublished - 2001

ASJC Scopus subject areas

  • Chemistry(all)


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