Suppression of induced humoral autoimmune response by dexamethasone in rats

Sudesh P Makker

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The effect of dexamethasone on the humoral antibody response to sheep red blood cells (SRBC) and on the humoral autoantibody response to a renal tubular antigen was studied in rats. The Heymann model of autoimmune, immune complex-induced glomerulonephritis was employed for studying the autoimmune response. It was found that dexamethasone did not appear to have much effect on the humoral response to SRBC (P >0.05), but it had a pronounced effect on the humoral autoantibody response (P <0.0001). These results may be interpreted to suggest that, in rats, the cellular events and the mechanism of humoral autoantibody response may be different from those involved in the generation of humoral antibody response to SRBC, because dexamethasone seems to have a pronounced effect on the former and very little on the latter.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalClinical and Experimental Immunology
Volume34
Issue number3
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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