Abstract
Arachidonic acid (AA) and certain prostagladins appear to antagonize GABAA receptors in synaptoneurosomes [18]. We report here that perfusing hippocampal slices with AA or prstaglandin F2α diminishes evoked IPSP conductance and increases CA1 pyramidal cell input resistance. The effects of the two compounds were similar, though not identical, in time course, magnitude, and response to washout. These findings suggest that high levels of AA and its metabolites may bias neurons towards excitation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 223-228 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 691 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Sep 11 1995 |
| Externally published | Yes |
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Keywords
- CA1
- Eicosanoid
- Epilepsy
- Excitotoxicity
- Hippocampus
- Input resistance
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Suppression of evoked IPSPs by arachidonic acid and prostaglandin F2α. / Owens, James; Schwartzkroin, Philip A.
In: Brain Research, Vol. 691, No. 1-2, 11.09.1995, p. 223-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of evoked IPSPs by arachidonic acid and prostaglandin F2α
AU - Owens, James
AU - Schwartzkroin, Philip A
PY - 1995/9/11
Y1 - 1995/9/11
N2 - Arachidonic acid (AA) and certain prostagladins appear to antagonize GABAA receptors in synaptoneurosomes [18]. We report here that perfusing hippocampal slices with AA or prstaglandin F2α diminishes evoked IPSP conductance and increases CA1 pyramidal cell input resistance. The effects of the two compounds were similar, though not identical, in time course, magnitude, and response to washout. These findings suggest that high levels of AA and its metabolites may bias neurons towards excitation.
AB - Arachidonic acid (AA) and certain prostagladins appear to antagonize GABAA receptors in synaptoneurosomes [18]. We report here that perfusing hippocampal slices with AA or prstaglandin F2α diminishes evoked IPSP conductance and increases CA1 pyramidal cell input resistance. The effects of the two compounds were similar, though not identical, in time course, magnitude, and response to washout. These findings suggest that high levels of AA and its metabolites may bias neurons towards excitation.
KW - CA1
KW - Eicosanoid
KW - Epilepsy
KW - Excitotoxicity
KW - Hippocampus
KW - Input resistance
UR - http://www.scopus.com/inward/record.url?scp=0029163148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029163148&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(95)00405-F
DO - 10.1016/0006-8993(95)00405-F
M3 - Article
C2 - 8590057
AN - SCOPUS:0029163148
VL - 691
SP - 223
EP - 228
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -