Suppression of evoked IPSPs by arachidonic acid and prostaglandin F

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Abstract

Arachidonic acid (AA) and certain prostagladins appear to antagonize GABAA receptors in synaptoneurosomes [18]. We report here that perfusing hippocampal slices with AA or prstaglandin F diminishes evoked IPSP conductance and increases CA1 pyramidal cell input resistance. The effects of the two compounds were similar, though not identical, in time course, magnitude, and response to washout. These findings suggest that high levels of AA and its metabolites may bias neurons towards excitation.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalBrain Research
Volume691
Issue number1-2
DOIs
StatePublished - Sep 11 1995
Externally publishedYes

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Keywords

  • CA1
  • Eicosanoid
  • Epilepsy
  • Excitotoxicity
  • Hippocampus
  • Input resistance

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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