Abstract
Arachidonic acid (AA) and certain prostagladins appear to antagonize GABAA receptors in synaptoneurosomes [18]. We report here that perfusing hippocampal slices with AA or prstaglandin F2α diminishes evoked IPSP conductance and increases CA1 pyramidal cell input resistance. The effects of the two compounds were similar, though not identical, in time course, magnitude, and response to washout. These findings suggest that high levels of AA and its metabolites may bias neurons towards excitation.
Original language | English (US) |
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Pages (from-to) | 223-228 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 691 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 11 1995 |
Externally published | Yes |
Keywords
- CA1
- Eicosanoid
- Epilepsy
- Excitotoxicity
- Hippocampus
- Input resistance
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)