Abstract
The c-fos immediate-early gene is induced by morphine and other drugs of abuse in the nucleus accumbens (NAc), a mesolimbic region implicated in drug abuse and reward. This study examined the role of c-fos in the acquisition and expression of the conditioned place paradigm (CPP) in the rat by suppressing Fos protein expression with c-fos antisense oligodeoxynucleotides (ODNs). CPP was completely prevented by c-fos antisense ODN infused bilaterally into the NAc prior to each systemic morphine injection, whereas sense and missense NAc injections had no effect on CPP. NAc administration of c-fos antisense ODN after the last systemic morphine conditioning session did not affect the expression of morphine-CPP. These results suggest that c-fos expression in NAc is necessary for the acquisition but not expression of morphine-CPP, and they have important implications for understanding conditioned behaviours and drug craving and addiction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3399-3406 |
| Number of pages | 8 |
| Journal | European Journal of Neuroscience |
| Volume | 12 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
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Keywords
- Addiction
- Antisense
- Conditioned place preference
- Drug abuse
- Fos
- Immediate-early gene
- Morphine
- Rat
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference. / Tolliver, Bryan K.; Sganga, Michael W.; Sharp, Frank R.
In: European Journal of Neuroscience, Vol. 12, No. 9, 2000, p. 3399-3406.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference
AU - Tolliver, Bryan K.
AU - Sganga, Michael W.
AU - Sharp, Frank R
PY - 2000
Y1 - 2000
N2 - The c-fos immediate-early gene is induced by morphine and other drugs of abuse in the nucleus accumbens (NAc), a mesolimbic region implicated in drug abuse and reward. This study examined the role of c-fos in the acquisition and expression of the conditioned place paradigm (CPP) in the rat by suppressing Fos protein expression with c-fos antisense oligodeoxynucleotides (ODNs). CPP was completely prevented by c-fos antisense ODN infused bilaterally into the NAc prior to each systemic morphine injection, whereas sense and missense NAc injections had no effect on CPP. NAc administration of c-fos antisense ODN after the last systemic morphine conditioning session did not affect the expression of morphine-CPP. These results suggest that c-fos expression in NAc is necessary for the acquisition but not expression of morphine-CPP, and they have important implications for understanding conditioned behaviours and drug craving and addiction.
AB - The c-fos immediate-early gene is induced by morphine and other drugs of abuse in the nucleus accumbens (NAc), a mesolimbic region implicated in drug abuse and reward. This study examined the role of c-fos in the acquisition and expression of the conditioned place paradigm (CPP) in the rat by suppressing Fos protein expression with c-fos antisense oligodeoxynucleotides (ODNs). CPP was completely prevented by c-fos antisense ODN infused bilaterally into the NAc prior to each systemic morphine injection, whereas sense and missense NAc injections had no effect on CPP. NAc administration of c-fos antisense ODN after the last systemic morphine conditioning session did not affect the expression of morphine-CPP. These results suggest that c-fos expression in NAc is necessary for the acquisition but not expression of morphine-CPP, and they have important implications for understanding conditioned behaviours and drug craving and addiction.
KW - Addiction
KW - Antisense
KW - Conditioned place preference
KW - Drug abuse
KW - Fos
KW - Immediate-early gene
KW - Morphine
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0033802685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033802685&partnerID=8YFLogxK
U2 - 10.1046/j.1460-9568.2000.00214.x
DO - 10.1046/j.1460-9568.2000.00214.x
M3 - Article
C2 - 10998122
AN - SCOPUS:0033802685
VL - 12
SP - 3399
EP - 3406
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 9
ER -