Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference

Bryan K. Tolliver, Michael W. Sganga, Frank R Sharp

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The c-fos immediate-early gene is induced by morphine and other drugs of abuse in the nucleus accumbens (NAc), a mesolimbic region implicated in drug abuse and reward. This study examined the role of c-fos in the acquisition and expression of the conditioned place paradigm (CPP) in the rat by suppressing Fos protein expression with c-fos antisense oligodeoxynucleotides (ODNs). CPP was completely prevented by c-fos antisense ODN infused bilaterally into the NAc prior to each systemic morphine injection, whereas sense and missense NAc injections had no effect on CPP. NAc administration of c-fos antisense ODN after the last systemic morphine conditioning session did not affect the expression of morphine-CPP. These results suggest that c-fos expression in NAc is necessary for the acquisition but not expression of morphine-CPP, and they have important implications for understanding conditioned behaviours and drug craving and addiction.

Original languageEnglish (US)
Pages (from-to)3399-3406
Number of pages8
JournalEuropean Journal of Neuroscience
Volume12
Issue number9
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Addiction
  • Antisense
  • Conditioned place preference
  • Drug abuse
  • Fos
  • Immediate-early gene
  • Morphine
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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