NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperplasia. Treatment with 2-week-old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X-irradiation.
|Original language||English (US)|
|Number of pages||4|
|Journal||Arthritis and Rheumatism|
|State||Published - Nov 1976|
ASJC Scopus subject areas