Suppression of autoimmunity in NZB mice with steroid-sensitive X-radiation-sensitive syngeneic young thymocytes.

R. O. Morton, D. G. Goodman, M. Eric Gershwin, C. Derkay, R. A. Squire, A. D. Steinberg

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperplasia. Treatment with 2-week-old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X-irradiation.

Original languageEnglish (US)
Pages (from-to)1347-1350
Number of pages4
JournalArthritis and Rheumatism
Volume19
Issue number6
StatePublished - Nov 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Morton, R. O., Goodman, D. G., Gershwin, M. E., Derkay, C., Squire, R. A., & Steinberg, A. D. (1976). Suppression of autoimmunity in NZB mice with steroid-sensitive X-radiation-sensitive syngeneic young thymocytes. Arthritis and Rheumatism, 19(6), 1347-1350.