Abstract
New Zealand (NZB) mice were monitored from either 4 or 10 wk of age with regard to onset and titer of a positive direct Coombs' test. Mice that were 4 wk of age at study entrance and who received intraperitoneal injections every 2 wk of ≤ 2-wk-old syngeneic thymocytes, remained Coombs' negative. Control mice, as well as mice receiving either syngenic young spleen cells, bone marrow cells, a combination of young thymocytes, spleen, and bone marrow cells, or old spleen cells, were uniformly Coombs' positive by 8 mo of age. Mice that were 10 wk of age, at the onset of the protocol, and that received syngeneic young thymocytes were identical to control animals. The relationship of suppressor cell function to autoimmunity is discussed in light of these findings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 38-45 |
| Number of pages | 8 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Suppression of autoimmune hemolytic anemia in New Zealand (NZB) mice by syngeneic young thymocytes. / Gershwin, M. Eric; Steinberg, Alfred D.
In: Clinical Immunology and Immunopathology, Vol. 4, No. 1, 1975, p. 38-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of autoimmune hemolytic anemia in New Zealand (NZB) mice by syngeneic young thymocytes
AU - Gershwin, M. Eric
AU - Steinberg, Alfred D.
PY - 1975
Y1 - 1975
N2 - New Zealand (NZB) mice were monitored from either 4 or 10 wk of age with regard to onset and titer of a positive direct Coombs' test. Mice that were 4 wk of age at study entrance and who received intraperitoneal injections every 2 wk of ≤ 2-wk-old syngeneic thymocytes, remained Coombs' negative. Control mice, as well as mice receiving either syngenic young spleen cells, bone marrow cells, a combination of young thymocytes, spleen, and bone marrow cells, or old spleen cells, were uniformly Coombs' positive by 8 mo of age. Mice that were 10 wk of age, at the onset of the protocol, and that received syngeneic young thymocytes were identical to control animals. The relationship of suppressor cell function to autoimmunity is discussed in light of these findings.
AB - New Zealand (NZB) mice were monitored from either 4 or 10 wk of age with regard to onset and titer of a positive direct Coombs' test. Mice that were 4 wk of age at study entrance and who received intraperitoneal injections every 2 wk of ≤ 2-wk-old syngeneic thymocytes, remained Coombs' negative. Control mice, as well as mice receiving either syngenic young spleen cells, bone marrow cells, a combination of young thymocytes, spleen, and bone marrow cells, or old spleen cells, were uniformly Coombs' positive by 8 mo of age. Mice that were 10 wk of age, at the onset of the protocol, and that received syngeneic young thymocytes were identical to control animals. The relationship of suppressor cell function to autoimmunity is discussed in light of these findings.
UR - http://www.scopus.com/inward/record.url?scp=0016698646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016698646&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(75)90037-9
DO - 10.1016/0090-1229(75)90037-9
M3 - Article
C2 - 1079173
AN - SCOPUS:0016698646
VL - 4
SP - 38
EP - 45
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 1
ER -