Supplementation of infant formula with bovine milk fat globule membranes

Niklas Timby, Magnus Domellöf, Bo Lönnerdal, Olle Hernell

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Studies have shown that supplementation of infant formula with bovine milk fat globule membranes (MFGMs) may substantially narrow the gap in health outcomes between formula-fed and breastfed infants. In one study, consumption of a formula supplemented with a lipid-rich MFGM concentrate between 2 and 6 mo ofage improved cognitive performance at 24 wkofage. In another study, a formula supplemented with a protein- rich MFGM concentrate given between 2 and 6 mo ofage improved cognitive performance at 12 mo ofage, decreased infectious morbidity until 6 mo ofage, and yielded serum cholesterol concentrations closer to those of breastfed infants. A third study that assessed the safety ofsupplementing infant formula with a lipid-rich or a protein-rich MFGM concentrate found a noninferior weight gain for both groups compared with a nonsupplemented formula. In this study, therewas an increased riskofeczema in the protein-rich group, but no seriousadverseevents. Infantformulas with supplemental MFGMs have been launched on the market in several countries. However, the evidence base must still be considered quite limited. Based on 3 randomized controlled trials that are not comparable, the intervention seems safe, but there is not enough evidence for a general recommendation on which MFGM fraction to use and at what concentration as formula supplement for a given outcome.

Original languageEnglish (US)
Pages (from-to)351-355
Number of pages5
JournalAdvances in Nutrition
Volume8
Issue number2
DOIs
StatePublished - Mar 1 2017

Keywords

  • Cholesterol
  • Cognition
  • Infant formula
  • Infection
  • MFGM
  • Neurodevelopment
  • Otitis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

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