TY - JOUR
T1 - Superparamagnetic nanoparticles as high efficiency magnetic resonance imaging T2 contrast agent
AU - Sousa, Fernanda
AU - Sanavio, Barbara
AU - Saccani, Alessandra
AU - Tang, Yun
AU - Zucca, Ileana
AU - Carney, Tamara M.
AU - Mastropietro, Alfonso
AU - Jacob Silva, Paulo H.
AU - Carney, Randy
AU - Schenk, Kurt
AU - Omrani, Arash O.
AU - Huang, Ping
AU - Yang, Lin
AU - Rønnow, Henrik M.
AU - Stellacci, Francesco
AU - Krol, Silke
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Nanoparticle-based magnetic resonance imaging T2 negative agents are of great interest, and much effort is devoted to increasing cellloading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nanoparticles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K. Furthermore, preliminary cellular studies reveal that both Au/Fe NPs show very limited toxicity. MRI phantom experiments show that r2/r1 ratio of Au/Fe NPs is as high as 670, leading to a 66% reduction in T2 relaxation time. These nanoparticles provide great versatility and potential for nanoparticle-based diagnostics and therapeutic applications and as imaging contrast agents.
AB - Nanoparticle-based magnetic resonance imaging T2 negative agents are of great interest, and much effort is devoted to increasing cellloading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nanoparticles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K. Furthermore, preliminary cellular studies reveal that both Au/Fe NPs show very limited toxicity. MRI phantom experiments show that r2/r1 ratio of Au/Fe NPs is as high as 670, leading to a 66% reduction in T2 relaxation time. These nanoparticles provide great versatility and potential for nanoparticle-based diagnostics and therapeutic applications and as imaging contrast agents.
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U2 - 10.1021/acs.bioconjchem.6b00577
DO - 10.1021/acs.bioconjchem.6b00577
M3 - Article
C2 - 28095682
AN - SCOPUS:85019560220
VL - 28
SP - 161
EP - 170
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 1
ER -