Superoxide dismutase activity and lipid peroxidation in the rat: Developmental correlations affected by manganese deficiency

S. Zidenberg Cherr, Carl L Keen, B. Lonnerdal, L. S. Hurley

Research output: Contribution to journalArticle

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Abstract

The activities of the mitochondrial enzyme manganese-superoxide dismutase (MnSOD), the cytosolic enzyme copper-zinc superoxide dismutase (CuZnSOD), and lipid peroxidation in liver were measured in manganese-sufficient and manganese-deficient rats from birth to 60 days of age. In both groups of rats there was an increase in MnSOD activity during development. In control rats MnSOD activity increased over sixfold between day 1 and day 60. However, in manganese-deficient animals the activity of this enzyme increased only threefold during this time period. In both groups of rats there was approximately a sixfold increase in CuZnSOD activity between day 1 and day 60. After day 10, CuZnSOD activity tended to be higher in Mn-deficient rats, with this difference being significant on day 15 (P > 0.01). Measurements of thiobarbituric acid-reacting products (TBA index) under conditions of oxidant stress suggested that there was a higher than normal level of mitochondrial lipid peroxidation in manganese-deficient rats by 60 days of age. Lipid peroxidation increased from day 1 to day 60 in both groups of rats, but a fivefold increase occurred in manganese-deficient rats while in controls the increase was only threefold. These findings suggest that the damage to mitochondrial membranes observed in manganese-deficient animals may be due to depressed MnSOD activity resulting in increased lipid peroxidation from free radicals.

Original languageEnglish (US)
Pages (from-to)2498-2504
Number of pages7
JournalJournal of Nutrition
Volume113
Issue number12
StatePublished - 1983

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Manganese
Lipid Peroxidation
Superoxide Dismutase
manganese
superoxide dismutase
lipid peroxidation
rats
Enzymes
Mitochondrial Membranes
Oxidants
thiobarbituric acid
Free Radicals
Zinc
Copper
enzymes
oxidants
Parturition
animals
copper
zinc

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Zidenberg Cherr, S., Keen, C. L., Lonnerdal, B., & Hurley, L. S. (1983). Superoxide dismutase activity and lipid peroxidation in the rat: Developmental correlations affected by manganese deficiency. Journal of Nutrition, 113(12), 2498-2504.

Superoxide dismutase activity and lipid peroxidation in the rat : Developmental correlations affected by manganese deficiency. / Zidenberg Cherr, S.; Keen, Carl L; Lonnerdal, B.; Hurley, L. S.

In: Journal of Nutrition, Vol. 113, No. 12, 1983, p. 2498-2504.

Research output: Contribution to journalArticle

Zidenberg Cherr, S, Keen, CL, Lonnerdal, B & Hurley, LS 1983, 'Superoxide dismutase activity and lipid peroxidation in the rat: Developmental correlations affected by manganese deficiency', Journal of Nutrition, vol. 113, no. 12, pp. 2498-2504.
Zidenberg Cherr, S. ; Keen, Carl L ; Lonnerdal, B. ; Hurley, L. S. / Superoxide dismutase activity and lipid peroxidation in the rat : Developmental correlations affected by manganese deficiency. In: Journal of Nutrition. 1983 ; Vol. 113, No. 12. pp. 2498-2504.
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