Superior temporal gyrus, language function, and autism

Erin D. Bigler, Sherstin Mortensen, E. Shannon Neeley, Sally J Ozonoff, Lori Krasny, Michael Johnson, Jeffrey Lu, Sherri L. Provencal, William McMahon, Janet E. Lainhart

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Deficits in language are a core feature of autism. The superior temporal gyrus (STG) is involved in auditory processing, including language, but also has been implicated as a critical structure in social cognition. It was hypothesized that subjects with autism would display different size-function relationships between the STG and intellectual-language-based abilities when compared to controls. Intellectual ability was assessed by either the Wechsler Intelligence Scale for Children-Third Edition (WISC-III) or Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), where three intellectual quotients (IQ) were computed: verbal (VIQ), performance (PIQ), and full-scale (FSIQ). Language ability was assessed by the Clinical Evaluation of Language Fundamentals-Third Edition (CELF-3), also divided into three index scores: receptive, expressive, and total. Seven to 19-year-old rigorously diagnosed subjects with autism (n = 30) were compared to controls (n = 39; 13 of whom had a deficit in reading) of similar age who were matched on education, PIQ, and head circumference. STG volumes were computed based on 1.5 Tesla magnetic resonance imaging (MRI). IQ and CELF-3 performance were highly interrelated regardless of whether subjects had autism or were controls. Both IQ and CELF-3 ability were positively correlated with STG in controls, but a different pattern was observed in subjects with autism. In controls, left STG gray matter was significantly (r = .42, p ≤ .05) related to receptive language on the CELF-3; in contrast, a zero order correlation was found with autism. When plotted by age, potential differences in growth trajectories related to language development associated with STG were observed between controls and those subjects with autism. Taken together, these findings suggest a possible failure in left hemisphere lateralization of language function involving the STG in autism. Superior Temporal Gyrus, Language Function, and Autism.

Original languageEnglish (US)
Pages (from-to)217-238
Number of pages22
JournalDevelopmental Neuropsychology
Volume31
Issue number2
StatePublished - 2007

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Temporal Lobe
Autistic Disorder
Language
Aptitude
Intelligence
Wechsler Scales
Language Development
Cognition
Reading
Head
Magnetic Resonance Imaging
Education
Growth

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental Neuroscience
  • Developmental and Educational Psychology
  • Experimental and Cognitive Psychology

Cite this

Bigler, E. D., Mortensen, S., Neeley, E. S., Ozonoff, S. J., Krasny, L., Johnson, M., ... Lainhart, J. E. (2007). Superior temporal gyrus, language function, and autism. Developmental Neuropsychology, 31(2), 217-238.

Superior temporal gyrus, language function, and autism. / Bigler, Erin D.; Mortensen, Sherstin; Neeley, E. Shannon; Ozonoff, Sally J; Krasny, Lori; Johnson, Michael; Lu, Jeffrey; Provencal, Sherri L.; McMahon, William; Lainhart, Janet E.

In: Developmental Neuropsychology, Vol. 31, No. 2, 2007, p. 217-238.

Research output: Contribution to journalArticle

Bigler, ED, Mortensen, S, Neeley, ES, Ozonoff, SJ, Krasny, L, Johnson, M, Lu, J, Provencal, SL, McMahon, W & Lainhart, JE 2007, 'Superior temporal gyrus, language function, and autism', Developmental Neuropsychology, vol. 31, no. 2, pp. 217-238.
Bigler ED, Mortensen S, Neeley ES, Ozonoff SJ, Krasny L, Johnson M et al. Superior temporal gyrus, language function, and autism. Developmental Neuropsychology. 2007;31(2):217-238.
Bigler, Erin D. ; Mortensen, Sherstin ; Neeley, E. Shannon ; Ozonoff, Sally J ; Krasny, Lori ; Johnson, Michael ; Lu, Jeffrey ; Provencal, Sherri L. ; McMahon, William ; Lainhart, Janet E. / Superior temporal gyrus, language function, and autism. In: Developmental Neuropsychology. 2007 ; Vol. 31, No. 2. pp. 217-238.
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