Superficial hypertrophic dendriform epitheliopathy: A follow-up series

W. Barry Lee, Mark J Mannis, Neal Mehra, Francisco Garcia-Ferrer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: To report the interval courses of previously reported cases of superficial hypertrophic dendriform epitheliopathy (SHDE) and to describe 3 new cases of this uncommon entity following penetrating keratoplasty. Method: Retrospective chart review. Results: We report follow-up on 3 previously described cases of SHDE, including discussion of cases and their clinical course. All 3 patients had persistent surface abnormalities complicating graft success resulting in poor visual outcomes. Three new cases of SHDE are discussed with a summary of the ocular findings and treatment. All patients underwent multiple penetrating keratoplasties for recurrent graft failures resulting from chronic postkeratoplasty surface keratopathy. Conclusions: SHDE is a rare complication of penetrating keratoplasty that can lead to delayed healing, chronic derangement of the corneal surface, corneal scarring, and an increased risk of graft rejection. Understanding and recognizing this entity is crucial for maximizing graft outcomes. Further investigation of the pathogenesis is necessary for complete understanding and management of the disorder.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
Issue number3
StatePublished - Apr 2006


  • Corneal surface
  • Dendriform epitheliopathy
  • Keratoplasty
  • Superficial hypertrophic dendriform epitheliopathy

ASJC Scopus subject areas

  • Ophthalmology


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