Super-localization of contrast agents in moving organs, first experiments in a rat kidney

Josquin Foiret, Hua Zhang, Lisa Mahakian, Sarah Tam, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Using individual microbubbles (MBs) to image vasculature with a spatial resolution below the diffraction limit has the potential to greatly improve the in vivo characterization of healthy and diseased tissue [1-2]. Recent studies have demonstrated a theoretical resolution on the order of microns in stationary tissue using standard imaging arrays [3]. However, the application of this technique to abdominal imaging brings new challenges due to the presence of physiological motion which is far larger than the achievable resolution. In this work, single MBs were localized in vivo in a rat kidney using a dedicated high frame rate (300 Hz) contrast pulse sequence (CPS) with spatial compounding (-5°, 0°, 5°). A stack of 60000 frames was acquired, providing a B-mode image to track tissue motion and a CPS image to track MB position at each time point. Acquisition was accomplished with a standard imaging array (CL15-7, ATL) driven at 6.9 MHz and a programmable ultrasound system (Verasonics). 3.4 million positions were detected and a density map of the MB positions was obtained after compensation for cardiac motion and changes in kidney position. Blood velocity was also estimated by tracking selected MBs over time.

Original languageEnglish (US)
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
ISBN (Electronic)9781467398978
StatePublished - Nov 1 2016
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: Sep 18 2016Sep 21 2016


Other2016 IEEE International Ultrasonics Symposium, IUS 2016


  • kidney imaging
  • microbubble
  • super resolution
  • ultrasound contrast agent
  • Vascular imaging

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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