31P spectroscopy in thrombolytic treatment of experimental cerebral infarct

B. C P Lee, J. M. Brock, T. Fan, J Anthony Seibert, C. Moonen, P. Kissel, B. Chehrazi, E. M. Bradbury

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalAmerican Journal of Roentgenology
Volume152
Issue number3
StatePublished - 1989

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Postmortem Changes
Tissue Plasminogen Activator
Spectrum Analysis
Coloring Agents
Arteries
Rabbits
Brain
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Lee, B. C. P., Brock, J. M., Fan, T., Seibert, J. A., Moonen, C., Kissel, P., ... Bradbury, E. M. (1989). 31P spectroscopy in thrombolytic treatment of experimental cerebral infarct. American Journal of Roentgenology, 152(3), 623-628.

31P spectroscopy in thrombolytic treatment of experimental cerebral infarct. / Lee, B. C P; Brock, J. M.; Fan, T.; Seibert, J Anthony; Moonen, C.; Kissel, P.; Chehrazi, B.; Bradbury, E. M.

In: American Journal of Roentgenology, Vol. 152, No. 3, 1989, p. 623-628.

Research output: Contribution to journalArticle

Lee, BCP, Brock, JM, Fan, T, Seibert, JA, Moonen, C, Kissel, P, Chehrazi, B & Bradbury, EM 1989, '31P spectroscopy in thrombolytic treatment of experimental cerebral infarct', American Journal of Roentgenology, vol. 152, no. 3, pp. 623-628.
Lee, B. C P ; Brock, J. M. ; Fan, T. ; Seibert, J Anthony ; Moonen, C. ; Kissel, P. ; Chehrazi, B. ; Bradbury, E. M. / 31P spectroscopy in thrombolytic treatment of experimental cerebral infarct. In: American Journal of Roentgenology. 1989 ; Vol. 152, No. 3. pp. 623-628.
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AU - Chehrazi, B.

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