31P spectroscopy in thrombolytic treatment of experimental cerebral infarct

B. C P Lee; J. M. Brock; T. Fan; J Anthony Seibert; C. Moonen; P. Kissel; B. Chehrazi; E. M. Bradbury

³¹P spectroscopy in thrombolytic treatment of experimental cerebral infarct

B. C P Lee, J. M. Brock, T. Fan, J Anthony Seibert, C. Moonen, P. Kissel, B. Chehrazi, E. M. Bradbury

Radiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil ³²P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the ³¹P spectrum correlated with postmortem changes.

Original language	English (US)
Pages (from-to)	623-628
Number of pages	6
Journal	American Journal of Roentgenology
Volume	152
Issue number	3
State	Published - 1989

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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title = "31P spectroscopy in thrombolytic treatment of experimental cerebral infarct",

abstract = "Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.",

author = "Lee, {B. C P} and Brock, {J. M.} and T. Fan and Seibert, {J Anthony} and C. Moonen and P. Kissel and B. Chehrazi and Bradbury, {E. M.}",

year = "1989",

language = "English (US)",

volume = "152",

pages = "623--628",

journal = "American Journal of Roentgenology",

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T1 - 31P spectroscopy in thrombolytic treatment of experimental cerebral infarct

AU - Lee, B. C P

AU - Brock, J. M.

AU - Fan, T.

AU - Seibert, J Anthony

AU - Moonen, C.

AU - Kissel, P.

AU - Chehrazi, B.

AU - Bradbury, E. M.

PY - 1989

Y1 - 1989

N2 - Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.

AB - Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.

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M3 - Article

C2 - 2464918

AN - SCOPUS:0024555750

VL - 152

SP - 623

EP - 628

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

SN - 0361-803X

IS - 3

ER -