Abstract
Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 623-628 |
| Number of pages | 6 |
| Journal | American Journal of Roentgenology |
| Volume | 152 |
| Issue number | 3 |
| State | Published - 1989 |
Fingerprint
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
31P spectroscopy in thrombolytic treatment of experimental cerebral infarct. / Lee, B. C P; Brock, J. M.; Fan, T.; Seibert, J Anthony; Moonen, C.; Kissel, P.; Chehrazi, B.; Bradbury, E. M.
In: American Journal of Roentgenology, Vol. 152, No. 3, 1989, p. 623-628.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 31P spectroscopy in thrombolytic treatment of experimental cerebral infarct
AU - Lee, B. C P
AU - Brock, J. M.
AU - Fan, T.
AU - Seibert, J Anthony
AU - Moonen, C.
AU - Kissel, P.
AU - Chehrazi, B.
AU - Bradbury, E. M.
PY - 1989
Y1 - 1989
N2 - Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.
AB - Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.
UR - http://www.scopus.com/inward/record.url?scp=0024555750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024555750&partnerID=8YFLogxK
M3 - Article
C2 - 2464918
AN - SCOPUS:0024555750
VL - 152
SP - 623
EP - 628
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
SN - 0361-803X
IS - 3
ER -