31P spectroscopy in thrombolytic treatment of experimental cerebral infarct

B. C P Lee, J. M. Brock, T. Fan, J Anthony Seibert, C. Moonen, P. Kissel, B. Chehrazi, E. M. Bradbury

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 32P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalAmerican Journal of Roentgenology
Issue number3
StatePublished - 1989

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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