31P NMR spectroscopy of the stomach by zig-zag coil

T. Nakada, Ingrid Kwee, T. Miyazaki, N. Iriguchi, T. Maki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Phosphorus-31 (31P) nuclear magnetic resonance (NMR) spectroscopic investigations of the rat stomach were performed utilizing a 1-cm2, three-turn, zig-zag coil. A zig-zag coil of this dimension produced an effective B1 field that extends only within a 4-mm distance from the plane of the surface coil, rendering it possible to obtain high-resolution 31P spectra localized to the stomach without contamination from surrounding tissues. Normal stomach showed a characteristic spectral pattern with resonances reflecting inorganic phosphate (P(i)), phosphocreatine (PCr), and the α-, β-, and γ-phosphates of adenosine triphosphate (ATP). Ischemia-induced changes in P(i)), PCr, and ATP resonances were readily followed in vivo with a time resolution of 2.13 min. Indomethacin-induced ulcer revealed a low intracellular pH and a decrease in the PCr to P(i)) ratio indicating the partially ischemic conditions of ulcerative lesions of the stomach as has been previously suggested. The present studies indicate that 31P NMR spectroscopy utilizing a zig-zag coil is a powerful tool to study local pathology of the gastrointestinal (GI) tract. Since zig-zag coils suitable for fiberscopic devices are easily constructed, clinical applications of the present technique are apparent.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalMagnetic Resonance in Medicine
Volume5
Issue number5
StatePublished - 1987

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Phosphocreatine
Stomach
Magnetic Resonance Spectroscopy
Adenosine Triphosphate
Phosphates
Indomethacin
Phosphorus
Ulcer
Gastrointestinal Tract
Ischemia
Pathology
Equipment and Supplies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Nakada, T., Kwee, I., Miyazaki, T., Iriguchi, N., & Maki, T. (1987). 31P NMR spectroscopy of the stomach by zig-zag coil. Magnetic Resonance in Medicine, 5(5), 449-455.

31P NMR spectroscopy of the stomach by zig-zag coil. / Nakada, T.; Kwee, Ingrid; Miyazaki, T.; Iriguchi, N.; Maki, T.

In: Magnetic Resonance in Medicine, Vol. 5, No. 5, 1987, p. 449-455.

Research output: Contribution to journalArticle

Nakada, T, Kwee, I, Miyazaki, T, Iriguchi, N & Maki, T 1987, '31P NMR spectroscopy of the stomach by zig-zag coil', Magnetic Resonance in Medicine, vol. 5, no. 5, pp. 449-455.
Nakada T, Kwee I, Miyazaki T, Iriguchi N, Maki T. 31P NMR spectroscopy of the stomach by zig-zag coil. Magnetic Resonance in Medicine. 1987;5(5):449-455.
Nakada, T. ; Kwee, Ingrid ; Miyazaki, T. ; Iriguchi, N. ; Maki, T. / 31P NMR spectroscopy of the stomach by zig-zag coil. In: Magnetic Resonance in Medicine. 1987 ; Vol. 5, No. 5. pp. 449-455.
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N2 - Phosphorus-31 (31P) nuclear magnetic resonance (NMR) spectroscopic investigations of the rat stomach were performed utilizing a 1-cm2, three-turn, zig-zag coil. A zig-zag coil of this dimension produced an effective B1 field that extends only within a 4-mm distance from the plane of the surface coil, rendering it possible to obtain high-resolution 31P spectra localized to the stomach without contamination from surrounding tissues. Normal stomach showed a characteristic spectral pattern with resonances reflecting inorganic phosphate (P(i)), phosphocreatine (PCr), and the α-, β-, and γ-phosphates of adenosine triphosphate (ATP). Ischemia-induced changes in P(i)), PCr, and ATP resonances were readily followed in vivo with a time resolution of 2.13 min. Indomethacin-induced ulcer revealed a low intracellular pH and a decrease in the PCr to P(i)) ratio indicating the partially ischemic conditions of ulcerative lesions of the stomach as has been previously suggested. The present studies indicate that 31P NMR spectroscopy utilizing a zig-zag coil is a powerful tool to study local pathology of the gastrointestinal (GI) tract. Since zig-zag coils suitable for fiberscopic devices are easily constructed, clinical applications of the present technique are apparent.

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