31P NMR spectroscopy of an experimentally induced intracerebral tumor in mice

Brian D. Ross, Robert Higgins, Frances K. Conley, Nancy S. True

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

31P surface coil NMR spectroscopy was used to evaluate in vivo high‐energy phosphorus metabolism in the brains of mice with experimentally induced primary intracranial and subcutaneous KHT sarcomas. 31P spectra of subcutaneous KHT tumors revealed a lack of detectable phosphocreatine (PCr) levels in the tumor as compared to the relatively high endogenous levels of PCr in normal mouse brain. As the intracerebral tumor size increased, there was a reduction in spectral PCr levels over a 23‐day postinoculation period in situ in the brain. No histologic or spectroscopic evidence of tumor‐associated necrosis or hypoxia was found. This study demonstrates that surface coil 31P NMR spectroscopy can be used to monitor changes in highenergy phosphate metabolism associated with progressive growth of an experimentally induced mouse brain tumor in situ. © 1987 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)323-332
Number of pages10
JournalMagnetic Resonance in Medicine
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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