1H NMR approach to observe tissue oxygenation with the signals of myoglobin

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Abstract

The myoglobin technique measures oxygen tension in myocytes. It relies on a quantitative measurement of the Val E11 and His F8 signals and an accurate value for the [O2]50 for Mb. Even though the Mb oxygen affinity in the cell is in question, the NMR results still reflect the degree of Mb oxygen saturation. Although magnetic resonance has established a variety of strategies to measure tissue oxygenation, the Mb approach is the most direct and will lead to a better understanding of oxygen's role in regulating cellular activity.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume361
StatePublished - 1994

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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