19F 2-FDG NMR imaging of the brain in rat

Tsutomu Nakada, Ingrid Kwee, Beatrice V. Griffey, Richard H. Griffey

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Images of the rat head reflecting glucose utilization were obtained using 2-fluoro-2-deoxy-D-glucose (2-FDG) and 19F nuclear magnetic resonance (NMR) imaging. Spatial heterogeneity of glucose utilization in the rat head was clearly demonstrated showing significantly higher glucose utilization in the brain as compared to the surrounding tissues. Although the potential adverse effects of the high doses of 2-FDG (400 mg/kg) needed to perform the study preclude immediate application of this technique to clinical quantitative glucose utilization studies, the present study shows potential for future development of glucose utilization imaging by NMR.

Original languageEnglish (US)
Pages (from-to)633-635
Number of pages3
JournalMagnetic Resonance Imaging
Volume6
Issue number6
DOIs
StatePublished - 1988

Keywords

  • 2-fluoro-2-deoxy-D-glucose
  • Cerebral glucose utilization
  • Nuclear magnetic resonance imaging

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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