18F-sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses

Mathieu Spriet, P. Espinosa, A. Z. Kyme, Kathryn L Phillips, Scott A Katzman, Larry D Galuppo, P. Stepanov, D. Beylin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Positron emission tomography (PET) is a cross-sectional, functional imaging modality that has recently become available to the horse. The use of 18F-sodium fluoride (18F-NaF), a PET bone tracer, has not previously been reported in this species. Objectives: To assess the feasibility of 18F-NaF PET in the equine distal limb and explore possible applications in the horse in comparison with other imaging modalities. Study design: Exploratory descriptive study involving three research horses. Methods: Horses were placed under general anaesthesia prior to intravenous (i.v.) administration of 1.5 MBq/kg of 18F-NaF. Positron emission tomography imaging of both front feet and fetlocks was performed using a portable scanner. Computed tomography (CT) of the distal limb was performed under a separate anaesthetic episode. Bone scintigraphy and magnetic resonance imaging (MRI) were subsequently performed under standing sedation. Images obtained from PET and other imaging modalities were independently assessed and the results correlated. Results: Positron emission tomography images were obtained without complication. The radiation exposure rate was similar to equine bone scintigraphy. Positron emission tomography detected focal 18F-NaF uptake in areas where other imaging modalities did not identify any abnormalities. This included sites of ligamentous attachment, subchondral compact bone plate and the flexor cortex of the navicular bone. 18F-NaF uptake was identified in some, but not all, osseous fragments and areas of osseous formation, suggesting a distinction between active and inactive lesions. Main limitations: A small number of horses were included and histopathology was not available. Conclusions: 18F-NaF PET imaging of the equine distal limb provides useful additional information when compared with CT, MRI and scintigraphy and has the potential for both research and clinical applications in the horse. The Summary is available in Chinese - see Supporting information.

Original languageEnglish (US)
JournalEquine Veterinary Journal
DOIs
StateAccepted/In press - 2017

Fingerprint

sodium fluoride
positron-emission tomography
Sodium Fluoride
limbs (animal)
Positron-Emission Tomography
Horses
Extremities
horses
image analysis
scintigraphy
bones
Radionuclide Imaging
Bone and Bones
computed tomography
magnetic resonance imaging
Tomography
Magnetic Resonance Imaging
Bone Plates
descriptive studies
scanners

Keywords

  • Bone
  • Functional
  • Horse
  • Imaging
  • Nuclear medicine
  • Remodelling

ASJC Scopus subject areas

  • Equine

Cite this

@article{3614192ffaff42b39417d96663d7b9d0,
title = "18F-sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses",
abstract = "Background: Positron emission tomography (PET) is a cross-sectional, functional imaging modality that has recently become available to the horse. The use of 18F-sodium fluoride (18F-NaF), a PET bone tracer, has not previously been reported in this species. Objectives: To assess the feasibility of 18F-NaF PET in the equine distal limb and explore possible applications in the horse in comparison with other imaging modalities. Study design: Exploratory descriptive study involving three research horses. Methods: Horses were placed under general anaesthesia prior to intravenous (i.v.) administration of 1.5 MBq/kg of 18F-NaF. Positron emission tomography imaging of both front feet and fetlocks was performed using a portable scanner. Computed tomography (CT) of the distal limb was performed under a separate anaesthetic episode. Bone scintigraphy and magnetic resonance imaging (MRI) were subsequently performed under standing sedation. Images obtained from PET and other imaging modalities were independently assessed and the results correlated. Results: Positron emission tomography images were obtained without complication. The radiation exposure rate was similar to equine bone scintigraphy. Positron emission tomography detected focal 18F-NaF uptake in areas where other imaging modalities did not identify any abnormalities. This included sites of ligamentous attachment, subchondral compact bone plate and the flexor cortex of the navicular bone. 18F-NaF uptake was identified in some, but not all, osseous fragments and areas of osseous formation, suggesting a distinction between active and inactive lesions. Main limitations: A small number of horses were included and histopathology was not available. Conclusions: 18F-NaF PET imaging of the equine distal limb provides useful additional information when compared with CT, MRI and scintigraphy and has the potential for both research and clinical applications in the horse. The Summary is available in Chinese - see Supporting information.",
keywords = "Bone, Functional, Horse, Imaging, Nuclear medicine, Remodelling",
author = "Mathieu Spriet and P. Espinosa and Kyme, {A. Z.} and Phillips, {Kathryn L} and Katzman, {Scott A} and Galuppo, {Larry D} and P. Stepanov and D. Beylin",
year = "2017",
doi = "10.1111/evj.12719",
language = "English (US)",
journal = "Equine veterinary journal. Supplement",
issn = "2042-3306",
publisher = "British Equine Veterinary Association",

}

TY - JOUR

T1 - 18F-sodium fluoride positron emission tomography of the equine distal limb

T2 - Exploratory study in three horses

AU - Spriet, Mathieu

AU - Espinosa, P.

AU - Kyme, A. Z.

AU - Phillips, Kathryn L

AU - Katzman, Scott A

AU - Galuppo, Larry D

AU - Stepanov, P.

AU - Beylin, D.

PY - 2017

Y1 - 2017

N2 - Background: Positron emission tomography (PET) is a cross-sectional, functional imaging modality that has recently become available to the horse. The use of 18F-sodium fluoride (18F-NaF), a PET bone tracer, has not previously been reported in this species. Objectives: To assess the feasibility of 18F-NaF PET in the equine distal limb and explore possible applications in the horse in comparison with other imaging modalities. Study design: Exploratory descriptive study involving three research horses. Methods: Horses were placed under general anaesthesia prior to intravenous (i.v.) administration of 1.5 MBq/kg of 18F-NaF. Positron emission tomography imaging of both front feet and fetlocks was performed using a portable scanner. Computed tomography (CT) of the distal limb was performed under a separate anaesthetic episode. Bone scintigraphy and magnetic resonance imaging (MRI) were subsequently performed under standing sedation. Images obtained from PET and other imaging modalities were independently assessed and the results correlated. Results: Positron emission tomography images were obtained without complication. The radiation exposure rate was similar to equine bone scintigraphy. Positron emission tomography detected focal 18F-NaF uptake in areas where other imaging modalities did not identify any abnormalities. This included sites of ligamentous attachment, subchondral compact bone plate and the flexor cortex of the navicular bone. 18F-NaF uptake was identified in some, but not all, osseous fragments and areas of osseous formation, suggesting a distinction between active and inactive lesions. Main limitations: A small number of horses were included and histopathology was not available. Conclusions: 18F-NaF PET imaging of the equine distal limb provides useful additional information when compared with CT, MRI and scintigraphy and has the potential for both research and clinical applications in the horse. The Summary is available in Chinese - see Supporting information.

AB - Background: Positron emission tomography (PET) is a cross-sectional, functional imaging modality that has recently become available to the horse. The use of 18F-sodium fluoride (18F-NaF), a PET bone tracer, has not previously been reported in this species. Objectives: To assess the feasibility of 18F-NaF PET in the equine distal limb and explore possible applications in the horse in comparison with other imaging modalities. Study design: Exploratory descriptive study involving three research horses. Methods: Horses were placed under general anaesthesia prior to intravenous (i.v.) administration of 1.5 MBq/kg of 18F-NaF. Positron emission tomography imaging of both front feet and fetlocks was performed using a portable scanner. Computed tomography (CT) of the distal limb was performed under a separate anaesthetic episode. Bone scintigraphy and magnetic resonance imaging (MRI) were subsequently performed under standing sedation. Images obtained from PET and other imaging modalities were independently assessed and the results correlated. Results: Positron emission tomography images were obtained without complication. The radiation exposure rate was similar to equine bone scintigraphy. Positron emission tomography detected focal 18F-NaF uptake in areas where other imaging modalities did not identify any abnormalities. This included sites of ligamentous attachment, subchondral compact bone plate and the flexor cortex of the navicular bone. 18F-NaF uptake was identified in some, but not all, osseous fragments and areas of osseous formation, suggesting a distinction between active and inactive lesions. Main limitations: A small number of horses were included and histopathology was not available. Conclusions: 18F-NaF PET imaging of the equine distal limb provides useful additional information when compared with CT, MRI and scintigraphy and has the potential for both research and clinical applications in the horse. The Summary is available in Chinese - see Supporting information.

KW - Bone

KW - Functional

KW - Horse

KW - Imaging

KW - Nuclear medicine

KW - Remodelling

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JO - Equine veterinary journal. Supplement

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