[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation

T. S. Kilduff, Frank R Sharp, H. C. Heller

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Autoradiographic patterns of [14C]2-deoxyglucose uptake are described throughout the brains of hibernating and euthermic ground squirrels. Autoradiographs of the brains of hibernating animals are generally homogeneous in comparison to euthermic animals; hence, the relative 2-deoxyglucose uptake (R2DGU) of gray to white matter for the majority of the 85 neural structures examined decreases during hibernation. Two categories of structures are identified as potentially important in hibernation: structures that have the highest R2DGU during hibernation (cochlear nucleus, paratrigeminal nucleus, and superior colliculus) and structures that undergo the least reduction in R2DGU in the transition from euthermia to hibernation (suprachiasmatic nucleus and lateral septal nucleus). The percentage of reduction in R2DGU that a structure undergoes in the transition from euthermia to hibernation is proportional to the R2DGU of that structure during euthermia. The suprachiasmatic, paratrigeminal, and cochlear nuclei undergo less of a reduction than would be predicted from this relationship and may be particularly important during hibernation. Sensory nuclei that receive primary afferent projections are among the structures with the highest R2DGU during hibernation. These metabolically active structures may be responsible for the sensitivity of the hibernator to environmental stimuli.

Original languageEnglish (US)
Pages (from-to)143-157
Number of pages15
JournalJournal of Neuroscience
Volume2
Issue number2
StatePublished - 1982
Externally publishedYes

Fingerprint

Hibernation
Sciuridae
Deoxyglucose
Brain
Cochlear Nucleus
Suprachiasmatic Nucleus
Septal Nuclei
Superior Colliculi

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation. / Kilduff, T. S.; Sharp, Frank R; Heller, H. C.

In: Journal of Neuroscience, Vol. 2, No. 2, 1982, p. 143-157.

Research output: Contribution to journalArticle

Kilduff, T. S. ; Sharp, Frank R ; Heller, H. C. / [14C]2-deoxyglucose uptake in ground squirrel brain during hibernation. In: Journal of Neuroscience. 1982 ; Vol. 2, No. 2. pp. 143-157.
@article{0d0da9147d0f470fb9de2a91cbaa1e70,
title = "[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation",
abstract = "Autoradiographic patterns of [14C]2-deoxyglucose uptake are described throughout the brains of hibernating and euthermic ground squirrels. Autoradiographs of the brains of hibernating animals are generally homogeneous in comparison to euthermic animals; hence, the relative 2-deoxyglucose uptake (R2DGU) of gray to white matter for the majority of the 85 neural structures examined decreases during hibernation. Two categories of structures are identified as potentially important in hibernation: structures that have the highest R2DGU during hibernation (cochlear nucleus, paratrigeminal nucleus, and superior colliculus) and structures that undergo the least reduction in R2DGU in the transition from euthermia to hibernation (suprachiasmatic nucleus and lateral septal nucleus). The percentage of reduction in R2DGU that a structure undergoes in the transition from euthermia to hibernation is proportional to the R2DGU of that structure during euthermia. The suprachiasmatic, paratrigeminal, and cochlear nuclei undergo less of a reduction than would be predicted from this relationship and may be particularly important during hibernation. Sensory nuclei that receive primary afferent projections are among the structures with the highest R2DGU during hibernation. These metabolically active structures may be responsible for the sensitivity of the hibernator to environmental stimuli.",
author = "Kilduff, {T. S.} and Sharp, {Frank R} and Heller, {H. C.}",
year = "1982",
language = "English (US)",
volume = "2",
pages = "143--157",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "2",

}

TY - JOUR

T1 - [14C]2-deoxyglucose uptake in ground squirrel brain during hibernation

AU - Kilduff, T. S.

AU - Sharp, Frank R

AU - Heller, H. C.

PY - 1982

Y1 - 1982

N2 - Autoradiographic patterns of [14C]2-deoxyglucose uptake are described throughout the brains of hibernating and euthermic ground squirrels. Autoradiographs of the brains of hibernating animals are generally homogeneous in comparison to euthermic animals; hence, the relative 2-deoxyglucose uptake (R2DGU) of gray to white matter for the majority of the 85 neural structures examined decreases during hibernation. Two categories of structures are identified as potentially important in hibernation: structures that have the highest R2DGU during hibernation (cochlear nucleus, paratrigeminal nucleus, and superior colliculus) and structures that undergo the least reduction in R2DGU in the transition from euthermia to hibernation (suprachiasmatic nucleus and lateral septal nucleus). The percentage of reduction in R2DGU that a structure undergoes in the transition from euthermia to hibernation is proportional to the R2DGU of that structure during euthermia. The suprachiasmatic, paratrigeminal, and cochlear nuclei undergo less of a reduction than would be predicted from this relationship and may be particularly important during hibernation. Sensory nuclei that receive primary afferent projections are among the structures with the highest R2DGU during hibernation. These metabolically active structures may be responsible for the sensitivity of the hibernator to environmental stimuli.

AB - Autoradiographic patterns of [14C]2-deoxyglucose uptake are described throughout the brains of hibernating and euthermic ground squirrels. Autoradiographs of the brains of hibernating animals are generally homogeneous in comparison to euthermic animals; hence, the relative 2-deoxyglucose uptake (R2DGU) of gray to white matter for the majority of the 85 neural structures examined decreases during hibernation. Two categories of structures are identified as potentially important in hibernation: structures that have the highest R2DGU during hibernation (cochlear nucleus, paratrigeminal nucleus, and superior colliculus) and structures that undergo the least reduction in R2DGU in the transition from euthermia to hibernation (suprachiasmatic nucleus and lateral septal nucleus). The percentage of reduction in R2DGU that a structure undergoes in the transition from euthermia to hibernation is proportional to the R2DGU of that structure during euthermia. The suprachiasmatic, paratrigeminal, and cochlear nuclei undergo less of a reduction than would be predicted from this relationship and may be particularly important during hibernation. Sensory nuclei that receive primary afferent projections are among the structures with the highest R2DGU during hibernation. These metabolically active structures may be responsible for the sensitivity of the hibernator to environmental stimuli.

UR - http://www.scopus.com/inward/record.url?scp=0020336518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020336518&partnerID=8YFLogxK

M3 - Article

C2 - 6278102

AN - SCOPUS:0020336518

VL - 2

SP - 143

EP - 157

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 2

ER -