Summer pheasant's eye (Adonis aestivalis) poisoning in three horses

Leslie Woods, M. S. Filigenzi, M. C. Booth, L. D. Rodger, J. S. Arnold, Birgit Puschner

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding initially presented with signs of colic 24-48 hours after first exposure to the hay. Gastrointestinal gaseous distension was the primary finding on clinical examination of all three horses. Two horses became moribund and were euthanatized 1 day after first showing clinical signs, and the third horse was euthanatized after 4 days of medical therapy. Endocardial hemorrhage and gaseous distension of the gastrointestinal tract were the only necropsy findings in the first two horses. On microscopic examination, both horses had scattered foci of mild, acute myocardial necrosis and neutrophilic inflammation associated with endocardial and epicardial hemorrhage. The third horse that survived for 4 days had multifocal to coalescing, irregular foci of acute, subacute, and chronic myocardial degeneration and necrosis. A. aestivalis (pheasant's eye, summer adonis) was identified in the hay. Strophanthidin, the aglycone of several cardenolides present in Adonis spp., was detected by liquid chromatography-mass spectrometry-mass spectrometry in gastrointestinal contents from all three horses. Although Adonis spp. contain cardiac glycosides, cardiac lesions have not previously been described in livestock associated with consumption of adonis, and this is the first report of adonis toxicosis in North America.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalVeterinary Pathology
Volume41
Issue number3
DOIs
StatePublished - May 2004

Fingerprint

Adonis
Poisoning
Horses
poisoning
horses
geldings
Cardenolides
cardenolides
hemorrhage
hay
necrosis
Appaloosa
Digitalis purpurea
Necrosis
Nerium
Strophanthidin
cardiac glycosides
Nerium oleander
Quarter Horse
Hemorrhage

Keywords

  • Adonis aestivalis
  • Adonis toxicosis
  • Colic
  • Equine
  • Myocardial degeneration
  • Myocarditis
  • Pheasant's eye
  • Strophanthin
  • Summer adonis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Summer pheasant's eye (Adonis aestivalis) poisoning in three horses. / Woods, Leslie; Filigenzi, M. S.; Booth, M. C.; Rodger, L. D.; Arnold, J. S.; Puschner, Birgit.

In: Veterinary Pathology, Vol. 41, No. 3, 05.2004, p. 215-220.

Research output: Contribution to journalArticle

Woods, Leslie ; Filigenzi, M. S. ; Booth, M. C. ; Rodger, L. D. ; Arnold, J. S. ; Puschner, Birgit. / Summer pheasant's eye (Adonis aestivalis) poisoning in three horses. In: Veterinary Pathology. 2004 ; Vol. 41, No. 3. pp. 215-220.
@article{fb128211865b40c08cb0eee3ee332434,
title = "Summer pheasant's eye (Adonis aestivalis) poisoning in three horses",
abstract = "Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding initially presented with signs of colic 24-48 hours after first exposure to the hay. Gastrointestinal gaseous distension was the primary finding on clinical examination of all three horses. Two horses became moribund and were euthanatized 1 day after first showing clinical signs, and the third horse was euthanatized after 4 days of medical therapy. Endocardial hemorrhage and gaseous distension of the gastrointestinal tract were the only necropsy findings in the first two horses. On microscopic examination, both horses had scattered foci of mild, acute myocardial necrosis and neutrophilic inflammation associated with endocardial and epicardial hemorrhage. The third horse that survived for 4 days had multifocal to coalescing, irregular foci of acute, subacute, and chronic myocardial degeneration and necrosis. A. aestivalis (pheasant's eye, summer adonis) was identified in the hay. Strophanthidin, the aglycone of several cardenolides present in Adonis spp., was detected by liquid chromatography-mass spectrometry-mass spectrometry in gastrointestinal contents from all three horses. Although Adonis spp. contain cardiac glycosides, cardiac lesions have not previously been described in livestock associated with consumption of adonis, and this is the first report of adonis toxicosis in North America.",
keywords = "Adonis aestivalis, Adonis toxicosis, Colic, Equine, Myocardial degeneration, Myocarditis, Pheasant's eye, Strophanthin, Summer adonis",
author = "Leslie Woods and Filigenzi, {M. S.} and Booth, {M. C.} and Rodger, {L. D.} and Arnold, {J. S.} and Birgit Puschner",
year = "2004",
month = "5",
doi = "10.1354/vp.41-3-215",
language = "English (US)",
volume = "41",
pages = "215--220",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Summer pheasant's eye (Adonis aestivalis) poisoning in three horses

AU - Woods, Leslie

AU - Filigenzi, M. S.

AU - Booth, M. C.

AU - Rodger, L. D.

AU - Arnold, J. S.

AU - Puschner, Birgit

PY - 2004/5

Y1 - 2004/5

N2 - Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding initially presented with signs of colic 24-48 hours after first exposure to the hay. Gastrointestinal gaseous distension was the primary finding on clinical examination of all three horses. Two horses became moribund and were euthanatized 1 day after first showing clinical signs, and the third horse was euthanatized after 4 days of medical therapy. Endocardial hemorrhage and gaseous distension of the gastrointestinal tract were the only necropsy findings in the first two horses. On microscopic examination, both horses had scattered foci of mild, acute myocardial necrosis and neutrophilic inflammation associated with endocardial and epicardial hemorrhage. The third horse that survived for 4 days had multifocal to coalescing, irregular foci of acute, subacute, and chronic myocardial degeneration and necrosis. A. aestivalis (pheasant's eye, summer adonis) was identified in the hay. Strophanthidin, the aglycone of several cardenolides present in Adonis spp., was detected by liquid chromatography-mass spectrometry-mass spectrometry in gastrointestinal contents from all three horses. Although Adonis spp. contain cardiac glycosides, cardiac lesions have not previously been described in livestock associated with consumption of adonis, and this is the first report of adonis toxicosis in North America.

AB - Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding initially presented with signs of colic 24-48 hours after first exposure to the hay. Gastrointestinal gaseous distension was the primary finding on clinical examination of all three horses. Two horses became moribund and were euthanatized 1 day after first showing clinical signs, and the third horse was euthanatized after 4 days of medical therapy. Endocardial hemorrhage and gaseous distension of the gastrointestinal tract were the only necropsy findings in the first two horses. On microscopic examination, both horses had scattered foci of mild, acute myocardial necrosis and neutrophilic inflammation associated with endocardial and epicardial hemorrhage. The third horse that survived for 4 days had multifocal to coalescing, irregular foci of acute, subacute, and chronic myocardial degeneration and necrosis. A. aestivalis (pheasant's eye, summer adonis) was identified in the hay. Strophanthidin, the aglycone of several cardenolides present in Adonis spp., was detected by liquid chromatography-mass spectrometry-mass spectrometry in gastrointestinal contents from all three horses. Although Adonis spp. contain cardiac glycosides, cardiac lesions have not previously been described in livestock associated with consumption of adonis, and this is the first report of adonis toxicosis in North America.

KW - Adonis aestivalis

KW - Adonis toxicosis

KW - Colic

KW - Equine

KW - Myocardial degeneration

KW - Myocarditis

KW - Pheasant's eye

KW - Strophanthin

KW - Summer adonis

UR - http://www.scopus.com/inward/record.url?scp=2542443498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542443498&partnerID=8YFLogxK

U2 - 10.1354/vp.41-3-215

DO - 10.1354/vp.41-3-215

M3 - Article

C2 - 15133169

AN - SCOPUS:2542443498

VL - 41

SP - 215

EP - 220

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 3

ER -