TY - JOUR
T1 - Summation of behavioral and immunological stress
T2 - Metabolic consequences to the growing mouse
AU - Laugero, Kevin D.
AU - Moberg, Gary P.
PY - 2000
Y1 - 2000
N2 - To address the hypothesis that multiple stressors can have cumulative effects on the individual, we determined the effects of restraint (R) stress (4 h/day for 7 days), immunological (L) stress [lipopolysac-charide (LPS) injection, 0.45 μg/g body wt on days 6 and 7], and R + L (RL) on the growth and energetics of C57Bl/6 male mice. R and L each repeatedly increased (P < 0.05) circulating corticosterone (>8 times), but RL caused even greater (>250%, P < 0.05) concentrations of circulating corticosterone than did either stressor alone. Only L and RL increased (P < 0.05) circulating interleukin-1β. Although R, L, and RL impaired growth (>75% below controls, P < 0.05), RL reduced growth to a greater extent. All stressors inhibited (P < 0.05) lean (>33% below controls) and fat (>120% below controls) energy deposition, and like the effects on growth, combined RL stress inhibited lean and fat energy deposition to a greater extent than did either stressor acting alone. These results demonstrated that the summation of multiple stress results in a cumulative cost to the growing animal.
AB - To address the hypothesis that multiple stressors can have cumulative effects on the individual, we determined the effects of restraint (R) stress (4 h/day for 7 days), immunological (L) stress [lipopolysac-charide (LPS) injection, 0.45 μg/g body wt on days 6 and 7], and R + L (RL) on the growth and energetics of C57Bl/6 male mice. R and L each repeatedly increased (P < 0.05) circulating corticosterone (>8 times), but RL caused even greater (>250%, P < 0.05) concentrations of circulating corticosterone than did either stressor alone. Only L and RL increased (P < 0.05) circulating interleukin-1β. Although R, L, and RL impaired growth (>75% below controls, P < 0.05), RL reduced growth to a greater extent. All stressors inhibited (P < 0.05) lean (>33% below controls) and fat (>120% below controls) energy deposition, and like the effects on growth, combined RL stress inhibited lean and fat energy deposition to a greater extent than did either stressor acting alone. These results demonstrated that the summation of multiple stress results in a cumulative cost to the growing animal.
KW - Corticosterone
KW - Energy partitioning
KW - Growth
KW - Interleukin-1
KW - Stress summation
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M3 - Article
C2 - 10893321
AN - SCOPUS:0033868588
VL - 279
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 1 42-1
ER -