Suggestive evidence for a quantitative trait locus on chromosome 3 for prepulse inhibition in the mouse

A. R. Sanders, R. Paylor, M. Libbey, J. Wang, Q. Cao, J. Zhang, L. R. Goldin, D. Pickar, E. S. Gershon, Jacqueline Crawley, P. V. Gejman

Research output: Contribution to journalArticle

Abstract

Objective: Schizophrenic patients display diminished prepulse inhibition (PPI) of the acoustic startle response. Thus, PPI in rodents may be used as an animal model for a neurophysiological trait in schizophrenia amenable to quantitative trait loci (QTL) mapping. Method: From an F2 intercross generation of C57BL/ 6J mice (diminished PPI) with AKR/J mice (normal PPI), we have genotyped 96 mice with extreme PPI using 121 markers covering the mouse genome at least every 20 cM. Mapmaker/QTL was used to search for areas of mouse chromosomes exhibiting a higher correlation of marker similarity to PPI score than expected by chance. Results: Heritability for PPI is estimated to be 0.64 +/- 0.06 from the phenotyping data. The most interesting linkage results from the preliminary scan of the extreme PPI mice reveal a region near marker D3Mit25 showing a suggestive linkage (MLOD = 2.5; P < 0.0024) under recessive inheritance. Conclusions: There is reasonable preliminary evidence that PPI is transmitted via detectable QTLs from the initial measures in this F2 intercross design (C57BL/ 6JxAKR/J). We detected suggestive evidence for linkage of proximal chromosome 3 to PPI in the mouse, and are currently genotyping all 600 mice from the F2 intercross at the five most significant regions from the genomic scan of the extreme PPI mice, which we estimate will increase the available information by another 40-50%.

Original languageEnglish (US)
Pages (from-to)485
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number6
StatePublished - Nov 6 1998
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 3
Quantitative Trait Loci
Startle Reflex
Prepulse Inhibition
Inbred AKR Mouse
Inbred C57BL Mouse
Acoustics
Rodentia
Schizophrenia
Animal Models
Chromosomes
Genome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Sanders, A. R., Paylor, R., Libbey, M., Wang, J., Cao, Q., Zhang, J., ... Gejman, P. V. (1998). Suggestive evidence for a quantitative trait locus on chromosome 3 for prepulse inhibition in the mouse. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 485.

Suggestive evidence for a quantitative trait locus on chromosome 3 for prepulse inhibition in the mouse. / Sanders, A. R.; Paylor, R.; Libbey, M.; Wang, J.; Cao, Q.; Zhang, J.; Goldin, L. R.; Pickar, D.; Gershon, E. S.; Crawley, Jacqueline; Gejman, P. V.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 81, No. 6, 06.11.1998, p. 485.

Research output: Contribution to journalArticle

Sanders, AR, Paylor, R, Libbey, M, Wang, J, Cao, Q, Zhang, J, Goldin, LR, Pickar, D, Gershon, ES, Crawley, J & Gejman, PV 1998, 'Suggestive evidence for a quantitative trait locus on chromosome 3 for prepulse inhibition in the mouse', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 6, pp. 485.
Sanders, A. R. ; Paylor, R. ; Libbey, M. ; Wang, J. ; Cao, Q. ; Zhang, J. ; Goldin, L. R. ; Pickar, D. ; Gershon, E. S. ; Crawley, Jacqueline ; Gejman, P. V. / Suggestive evidence for a quantitative trait locus on chromosome 3 for prepulse inhibition in the mouse. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1998 ; Vol. 81, No. 6. pp. 485.
@article{4603f830f7454e73a04301a601c3e8e2,
title = "Suggestive evidence for a quantitative trait locus on chromosome 3 for prepulse inhibition in the mouse",
abstract = "Objective: Schizophrenic patients display diminished prepulse inhibition (PPI) of the acoustic startle response. Thus, PPI in rodents may be used as an animal model for a neurophysiological trait in schizophrenia amenable to quantitative trait loci (QTL) mapping. Method: From an F2 intercross generation of C57BL/ 6J mice (diminished PPI) with AKR/J mice (normal PPI), we have genotyped 96 mice with extreme PPI using 121 markers covering the mouse genome at least every 20 cM. Mapmaker/QTL was used to search for areas of mouse chromosomes exhibiting a higher correlation of marker similarity to PPI score than expected by chance. Results: Heritability for PPI is estimated to be 0.64 +/- 0.06 from the phenotyping data. The most interesting linkage results from the preliminary scan of the extreme PPI mice reveal a region near marker D3Mit25 showing a suggestive linkage (MLOD = 2.5; P < 0.0024) under recessive inheritance. Conclusions: There is reasonable preliminary evidence that PPI is transmitted via detectable QTLs from the initial measures in this F2 intercross design (C57BL/ 6JxAKR/J). We detected suggestive evidence for linkage of proximal chromosome 3 to PPI in the mouse, and are currently genotyping all 600 mice from the F2 intercross at the five most significant regions from the genomic scan of the extreme PPI mice, which we estimate will increase the available information by another 40-50{\%}.",
author = "Sanders, {A. R.} and R. Paylor and M. Libbey and J. Wang and Q. Cao and J. Zhang and Goldin, {L. R.} and D. Pickar and Gershon, {E. S.} and Jacqueline Crawley and Gejman, {P. V.}",
year = "1998",
month = "11",
day = "6",
language = "English (US)",
volume = "81",
pages = "485",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Suggestive evidence for a quantitative trait locus on chromosome 3 for prepulse inhibition in the mouse

AU - Sanders, A. R.

AU - Paylor, R.

AU - Libbey, M.

AU - Wang, J.

AU - Cao, Q.

AU - Zhang, J.

AU - Goldin, L. R.

AU - Pickar, D.

AU - Gershon, E. S.

AU - Crawley, Jacqueline

AU - Gejman, P. V.

PY - 1998/11/6

Y1 - 1998/11/6

N2 - Objective: Schizophrenic patients display diminished prepulse inhibition (PPI) of the acoustic startle response. Thus, PPI in rodents may be used as an animal model for a neurophysiological trait in schizophrenia amenable to quantitative trait loci (QTL) mapping. Method: From an F2 intercross generation of C57BL/ 6J mice (diminished PPI) with AKR/J mice (normal PPI), we have genotyped 96 mice with extreme PPI using 121 markers covering the mouse genome at least every 20 cM. Mapmaker/QTL was used to search for areas of mouse chromosomes exhibiting a higher correlation of marker similarity to PPI score than expected by chance. Results: Heritability for PPI is estimated to be 0.64 +/- 0.06 from the phenotyping data. The most interesting linkage results from the preliminary scan of the extreme PPI mice reveal a region near marker D3Mit25 showing a suggestive linkage (MLOD = 2.5; P < 0.0024) under recessive inheritance. Conclusions: There is reasonable preliminary evidence that PPI is transmitted via detectable QTLs from the initial measures in this F2 intercross design (C57BL/ 6JxAKR/J). We detected suggestive evidence for linkage of proximal chromosome 3 to PPI in the mouse, and are currently genotyping all 600 mice from the F2 intercross at the five most significant regions from the genomic scan of the extreme PPI mice, which we estimate will increase the available information by another 40-50%.

AB - Objective: Schizophrenic patients display diminished prepulse inhibition (PPI) of the acoustic startle response. Thus, PPI in rodents may be used as an animal model for a neurophysiological trait in schizophrenia amenable to quantitative trait loci (QTL) mapping. Method: From an F2 intercross generation of C57BL/ 6J mice (diminished PPI) with AKR/J mice (normal PPI), we have genotyped 96 mice with extreme PPI using 121 markers covering the mouse genome at least every 20 cM. Mapmaker/QTL was used to search for areas of mouse chromosomes exhibiting a higher correlation of marker similarity to PPI score than expected by chance. Results: Heritability for PPI is estimated to be 0.64 +/- 0.06 from the phenotyping data. The most interesting linkage results from the preliminary scan of the extreme PPI mice reveal a region near marker D3Mit25 showing a suggestive linkage (MLOD = 2.5; P < 0.0024) under recessive inheritance. Conclusions: There is reasonable preliminary evidence that PPI is transmitted via detectable QTLs from the initial measures in this F2 intercross design (C57BL/ 6JxAKR/J). We detected suggestive evidence for linkage of proximal chromosome 3 to PPI in the mouse, and are currently genotyping all 600 mice from the F2 intercross at the five most significant regions from the genomic scan of the extreme PPI mice, which we estimate will increase the available information by another 40-50%.

UR - http://www.scopus.com/inward/record.url?scp=33749089499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749089499&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33749089499

VL - 81

SP - 485

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 6

ER -