Sugary beverage intake and preclinical Alzheimer's disease in the community

Matthew P. Pase, Jayandra J. Himali, Paul F. Jacques, Charles DeCarli, Claudia L. Satizabal, Hugo Aparicio, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction: Excess sugar consumption has been linked with Alzheimer's disease (AD) pathology in animal models. Methods: We examined the cross-sectional association of sugary beverage consumption with neuropsychological (N = 4276) and magnetic resonance imaging (N = 3846) markers of preclinical Alzheimer's disease and vascular brain injury (VBI) in the community-based Framingham Heart Study. Intake of sugary beverages was estimated using a food frequency questionnaire. Results: Relative to consuming less than one sugary beverage per day, higher intake of sugary beverages was associated with lower total brain volume (1-2/day, β ± standard error [SE] = -0.55 ± 0.14 mean percent difference, P = .0002; >2/day, β ± SE = -0.68 ± 0.18, P < .0001), and poorer performance on tests of episodic memory (all P < .01). Daily fruit juice intake was associated with lower total brain volume, hippocampal volume, and poorer episodic memory (all P < .05). Sugary beverage intake was not associated with VBI in a consistent manner across outcomes. Discussion: Higher intake of sugary beverages was associated cross-sectionally with markers of preclinical AD.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2017

Fingerprint

Beverages
Alzheimer Disease
Cerebrovascular Trauma
Episodic Memory
Brain
Animal Models
Magnetic Resonance Imaging
Pathology
Food

Keywords

  • Alzheimer's disease
  • Dementia
  • Diet
  • Framingham Heart Study
  • Sugar

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Pase, M. P., Himali, J. J., Jacques, P. F., DeCarli, C., Satizabal, C. L., Aparicio, H., ... Seshadri, S. (Accepted/In press). Sugary beverage intake and preclinical Alzheimer's disease in the community. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2017.01.024

Sugary beverage intake and preclinical Alzheimer's disease in the community. / Pase, Matthew P.; Himali, Jayandra J.; Jacques, Paul F.; DeCarli, Charles; Satizabal, Claudia L.; Aparicio, Hugo; Vasan, Ramachandran S.; Beiser, Alexa S.; Seshadri, Sudha.

In: Alzheimer's and Dementia, 2017.

Research output: Contribution to journalArticle

Pase, MP, Himali, JJ, Jacques, PF, DeCarli, C, Satizabal, CL, Aparicio, H, Vasan, RS, Beiser, AS & Seshadri, S 2017, 'Sugary beverage intake and preclinical Alzheimer's disease in the community', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2017.01.024
Pase, Matthew P. ; Himali, Jayandra J. ; Jacques, Paul F. ; DeCarli, Charles ; Satizabal, Claudia L. ; Aparicio, Hugo ; Vasan, Ramachandran S. ; Beiser, Alexa S. ; Seshadri, Sudha. / Sugary beverage intake and preclinical Alzheimer's disease in the community. In: Alzheimer's and Dementia. 2017.
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