Sudden cardiac death in South India

Incidence, risk factors and pathology

Uma N Srivatsa, K. Swaminathan, K. Sithy Athiya Munavarah, Ezra A Amsterdam, K. Shantaraman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Sudden cardiac death (SCD) is a major cause of mortality secondary to coronary artery disease (CAD) in the industrialized societies. Although South Asians have a high prevalence of CAD, the frequency and underlying pathology of SCD among this population are unknown. Methods Medical records of consecutive patients presenting with unexplained sudden death (USD) in a tertiary care center were reviewed. Patients with trauma, violent deaths, positive toxicology and non-cardiac pathology were excluded to determine sudden cardiac death (SCD). Cardiac pathological findings were analyzed by autopsy. SCD rate was estimated based on census and government vital statistics for the years studied. Results During a two year period, 223 patients (mean age 55 + 10 yrs, 78.9% male, body mass index 26 + 4, 60% smokers, 39% known CAD, 46% hypertension, 43% diabetes) presented to hospital with USD. SCD was attributed to myocardial infarction (MI) in 87% of cases; 69% were acute (96% anterior MI); 76% were small/moderate infarct and 9.9% of the cohort had normal hearts. Based on official municipal vital statistics, the SCD rate in those >35 yrs of age was estimated as 39.7/100,000 with male/female ratio of 4.6. Conclusions SCD in this south Indian city occurred predominantly in men of relatively young age and was most frequently associated with small or moderate-sized acute MI. Improved health care access, preventive measures and enhanced emergency management may reduce SCD from acute MI in this locale.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalIndian Pacing and Electrophysiology Journal
Volume16
Issue number4
DOIs
StatePublished - Jul 1 2016

Fingerprint

Sudden Cardiac Death
India
Pathology
Incidence
Myocardial Infarction
Coronary Artery Disease
Vital Statistics
Sudden Death
Mortality
Preventive Health Services
Censuses
Tertiary Care Centers
Toxicology
Medical Records
Autopsy
Body Mass Index
Emergencies
Hypertension
Wounds and Injuries
Population

Keywords

  • Autopsy
  • Risk factors
  • South India
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Sudden cardiac death in South India : Incidence, risk factors and pathology. / Srivatsa, Uma N; Swaminathan, K.; Sithy Athiya Munavarah, K.; Amsterdam, Ezra A; Shantaraman, K.

In: Indian Pacing and Electrophysiology Journal, Vol. 16, No. 4, 01.07.2016, p. 121-125.

Research output: Contribution to journalArticle

Srivatsa, Uma N ; Swaminathan, K. ; Sithy Athiya Munavarah, K. ; Amsterdam, Ezra A ; Shantaraman, K. / Sudden cardiac death in South India : Incidence, risk factors and pathology. In: Indian Pacing and Electrophysiology Journal. 2016 ; Vol. 16, No. 4. pp. 121-125.
@article{e37769c944eb466f950b57d4585b137a,
title = "Sudden cardiac death in South India: Incidence, risk factors and pathology",
abstract = "Background Sudden cardiac death (SCD) is a major cause of mortality secondary to coronary artery disease (CAD) in the industrialized societies. Although South Asians have a high prevalence of CAD, the frequency and underlying pathology of SCD among this population are unknown. Methods Medical records of consecutive patients presenting with unexplained sudden death (USD) in a tertiary care center were reviewed. Patients with trauma, violent deaths, positive toxicology and non-cardiac pathology were excluded to determine sudden cardiac death (SCD). Cardiac pathological findings were analyzed by autopsy. SCD rate was estimated based on census and government vital statistics for the years studied. Results During a two year period, 223 patients (mean age 55 + 10 yrs, 78.9{\%} male, body mass index 26 + 4, 60{\%} smokers, 39{\%} known CAD, 46{\%} hypertension, 43{\%} diabetes) presented to hospital with USD. SCD was attributed to myocardial infarction (MI) in 87{\%} of cases; 69{\%} were acute (96{\%} anterior MI); 76{\%} were small/moderate infarct and 9.9{\%} of the cohort had normal hearts. Based on official municipal vital statistics, the SCD rate in those >35 yrs of age was estimated as 39.7/100,000 with male/female ratio of 4.6. Conclusions SCD in this south Indian city occurred predominantly in men of relatively young age and was most frequently associated with small or moderate-sized acute MI. Improved health care access, preventive measures and enhanced emergency management may reduce SCD from acute MI in this locale.",
keywords = "Autopsy, Risk factors, South India, Sudden cardiac death",
author = "Srivatsa, {Uma N} and K. Swaminathan and {Sithy Athiya Munavarah}, K. and Amsterdam, {Ezra A} and K. Shantaraman",
year = "2016",
month = "7",
day = "1",
doi = "10.1016/j.ipej.2016.10.004",
language = "English (US)",
volume = "16",
pages = "121--125",
journal = "Indian Pacing and Electrophysiology Journal",
issn = "0972-6292",
publisher = "Indian Pacing and Electrophysiology Group",
number = "4",

}

TY - JOUR

T1 - Sudden cardiac death in South India

T2 - Incidence, risk factors and pathology

AU - Srivatsa, Uma N

AU - Swaminathan, K.

AU - Sithy Athiya Munavarah, K.

AU - Amsterdam, Ezra A

AU - Shantaraman, K.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background Sudden cardiac death (SCD) is a major cause of mortality secondary to coronary artery disease (CAD) in the industrialized societies. Although South Asians have a high prevalence of CAD, the frequency and underlying pathology of SCD among this population are unknown. Methods Medical records of consecutive patients presenting with unexplained sudden death (USD) in a tertiary care center were reviewed. Patients with trauma, violent deaths, positive toxicology and non-cardiac pathology were excluded to determine sudden cardiac death (SCD). Cardiac pathological findings were analyzed by autopsy. SCD rate was estimated based on census and government vital statistics for the years studied. Results During a two year period, 223 patients (mean age 55 + 10 yrs, 78.9% male, body mass index 26 + 4, 60% smokers, 39% known CAD, 46% hypertension, 43% diabetes) presented to hospital with USD. SCD was attributed to myocardial infarction (MI) in 87% of cases; 69% were acute (96% anterior MI); 76% were small/moderate infarct and 9.9% of the cohort had normal hearts. Based on official municipal vital statistics, the SCD rate in those >35 yrs of age was estimated as 39.7/100,000 with male/female ratio of 4.6. Conclusions SCD in this south Indian city occurred predominantly in men of relatively young age and was most frequently associated with small or moderate-sized acute MI. Improved health care access, preventive measures and enhanced emergency management may reduce SCD from acute MI in this locale.

AB - Background Sudden cardiac death (SCD) is a major cause of mortality secondary to coronary artery disease (CAD) in the industrialized societies. Although South Asians have a high prevalence of CAD, the frequency and underlying pathology of SCD among this population are unknown. Methods Medical records of consecutive patients presenting with unexplained sudden death (USD) in a tertiary care center were reviewed. Patients with trauma, violent deaths, positive toxicology and non-cardiac pathology were excluded to determine sudden cardiac death (SCD). Cardiac pathological findings were analyzed by autopsy. SCD rate was estimated based on census and government vital statistics for the years studied. Results During a two year period, 223 patients (mean age 55 + 10 yrs, 78.9% male, body mass index 26 + 4, 60% smokers, 39% known CAD, 46% hypertension, 43% diabetes) presented to hospital with USD. SCD was attributed to myocardial infarction (MI) in 87% of cases; 69% were acute (96% anterior MI); 76% were small/moderate infarct and 9.9% of the cohort had normal hearts. Based on official municipal vital statistics, the SCD rate in those >35 yrs of age was estimated as 39.7/100,000 with male/female ratio of 4.6. Conclusions SCD in this south Indian city occurred predominantly in men of relatively young age and was most frequently associated with small or moderate-sized acute MI. Improved health care access, preventive measures and enhanced emergency management may reduce SCD from acute MI in this locale.

KW - Autopsy

KW - Risk factors

KW - South India

KW - Sudden cardiac death

UR - http://www.scopus.com/inward/record.url?scp=84998693212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84998693212&partnerID=8YFLogxK

U2 - 10.1016/j.ipej.2016.10.004

DO - 10.1016/j.ipej.2016.10.004

M3 - Article

VL - 16

SP - 121

EP - 125

JO - Indian Pacing and Electrophysiology Journal

JF - Indian Pacing and Electrophysiology Journal

SN - 0972-6292

IS - 4

ER -