Successful verbal encoding into episodic memory engages the posterior hippocampus

A parametrically analyzed functional magnetic resonance imaging study

Guillén Fernández, Helga Weyerts, Michael Schrader-Bölsche, Indira Tendolkar, Henderikus G O M Smid, Claus Tempelmann, Hermann Hinrichs, Henning Scheich, Christian E. Elger, George R Mangun, Hans Jochen Heinze

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

The medial temporal lobe (MTL) is essential for episodic memory encoding, as evidenced by memory deficits in patients with MTL damage. However, previous functional neuroimaging studies have either failed to show MTL activation during encoding or they did not differentiate between two MTL related processes: novelty assessment and episodic memory encoding. Furthermore, there is evidence that the MTL can be subdivided into subcomponents serving different memory processes, but the extent of this functional subdivision remains unknown. The aim of the present functional magnetic resonance imaging (fMRI) study was to investigate the role of the MTL in episodic encoding and to determine whether this function might be restricted to anatomical subdivisions of the MTL. Thirteen healthy volunteers performed a word list learning paradigm with free recall after distraction. Functional images acquired during encoding were analyzed separately for each participant by a voxel-wise correlation (Kendall's tau) between the time series of the T2*- signal intensity and the number of subsequently recalled words encoded during each particular scan. Of the 13 participants, 11 showed voxel clusters with statistically significant, positive correlations in the posterior part of the hippocampus. Across participants, an ANOVA on the number of voxels with significant, positive correlations within individually defined volumes of interest confirmed a statistically significant difference in activation for anterior versus posterior regions of the hippocampus. However, no differences between left and right hippocampal activation were revealed. Thus, these findings demonstrate that successful encoding into episodic memory engages neural circuits in the posterior part of the hippocampus.

Original languageEnglish (US)
Pages (from-to)1841-1847
Number of pages7
JournalJournal of Neuroscience
Volume18
Issue number5
StatePublished - Mar 1 1998

Fingerprint

Episodic Memory
Temporal Lobe
Hippocampus
Magnetic Resonance Imaging
Functional Neuroimaging
Process Assessment (Health Care)
Memory Disorders
Analysis of Variance
Healthy Volunteers
Learning

Keywords

  • Alzheimer's disease
  • Declarative memory
  • Encoding
  • Episodic memory
  • fMRI
  • Functional neuroimaging
  • Hippocampus
  • Medial temporal lobe
  • Memory formation
  • Parametrical analysis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fernández, G., Weyerts, H., Schrader-Bölsche, M., Tendolkar, I., Smid, H. G. O. M., Tempelmann, C., ... Heinze, H. J. (1998). Successful verbal encoding into episodic memory engages the posterior hippocampus: A parametrically analyzed functional magnetic resonance imaging study. Journal of Neuroscience, 18(5), 1841-1847.

Successful verbal encoding into episodic memory engages the posterior hippocampus : A parametrically analyzed functional magnetic resonance imaging study. / Fernández, Guillén; Weyerts, Helga; Schrader-Bölsche, Michael; Tendolkar, Indira; Smid, Henderikus G O M; Tempelmann, Claus; Hinrichs, Hermann; Scheich, Henning; Elger, Christian E.; Mangun, George R; Heinze, Hans Jochen.

In: Journal of Neuroscience, Vol. 18, No. 5, 01.03.1998, p. 1841-1847.

Research output: Contribution to journalArticle

Fernández, G, Weyerts, H, Schrader-Bölsche, M, Tendolkar, I, Smid, HGOM, Tempelmann, C, Hinrichs, H, Scheich, H, Elger, CE, Mangun, GR & Heinze, HJ 1998, 'Successful verbal encoding into episodic memory engages the posterior hippocampus: A parametrically analyzed functional magnetic resonance imaging study', Journal of Neuroscience, vol. 18, no. 5, pp. 1841-1847.
Fernández G, Weyerts H, Schrader-Bölsche M, Tendolkar I, Smid HGOM, Tempelmann C et al. Successful verbal encoding into episodic memory engages the posterior hippocampus: A parametrically analyzed functional magnetic resonance imaging study. Journal of Neuroscience. 1998 Mar 1;18(5):1841-1847.
Fernández, Guillén ; Weyerts, Helga ; Schrader-Bölsche, Michael ; Tendolkar, Indira ; Smid, Henderikus G O M ; Tempelmann, Claus ; Hinrichs, Hermann ; Scheich, Henning ; Elger, Christian E. ; Mangun, George R ; Heinze, Hans Jochen. / Successful verbal encoding into episodic memory engages the posterior hippocampus : A parametrically analyzed functional magnetic resonance imaging study. In: Journal of Neuroscience. 1998 ; Vol. 18, No. 5. pp. 1841-1847.
@article{57032cf737eb42a6af8282fd43ffa7e0,
title = "Successful verbal encoding into episodic memory engages the posterior hippocampus: A parametrically analyzed functional magnetic resonance imaging study",
abstract = "The medial temporal lobe (MTL) is essential for episodic memory encoding, as evidenced by memory deficits in patients with MTL damage. However, previous functional neuroimaging studies have either failed to show MTL activation during encoding or they did not differentiate between two MTL related processes: novelty assessment and episodic memory encoding. Furthermore, there is evidence that the MTL can be subdivided into subcomponents serving different memory processes, but the extent of this functional subdivision remains unknown. The aim of the present functional magnetic resonance imaging (fMRI) study was to investigate the role of the MTL in episodic encoding and to determine whether this function might be restricted to anatomical subdivisions of the MTL. Thirteen healthy volunteers performed a word list learning paradigm with free recall after distraction. Functional images acquired during encoding were analyzed separately for each participant by a voxel-wise correlation (Kendall's tau) between the time series of the T2*- signal intensity and the number of subsequently recalled words encoded during each particular scan. Of the 13 participants, 11 showed voxel clusters with statistically significant, positive correlations in the posterior part of the hippocampus. Across participants, an ANOVA on the number of voxels with significant, positive correlations within individually defined volumes of interest confirmed a statistically significant difference in activation for anterior versus posterior regions of the hippocampus. However, no differences between left and right hippocampal activation were revealed. Thus, these findings demonstrate that successful encoding into episodic memory engages neural circuits in the posterior part of the hippocampus.",
keywords = "Alzheimer's disease, Declarative memory, Encoding, Episodic memory, fMRI, Functional neuroimaging, Hippocampus, Medial temporal lobe, Memory formation, Parametrical analysis",
author = "Guill{\'e}n Fern{\'a}ndez and Helga Weyerts and Michael Schrader-B{\"o}lsche and Indira Tendolkar and Smid, {Henderikus G O M} and Claus Tempelmann and Hermann Hinrichs and Henning Scheich and Elger, {Christian E.} and Mangun, {George R} and Heinze, {Hans Jochen}",
year = "1998",
month = "3",
day = "1",
language = "English (US)",
volume = "18",
pages = "1841--1847",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "5",

}

TY - JOUR

T1 - Successful verbal encoding into episodic memory engages the posterior hippocampus

T2 - A parametrically analyzed functional magnetic resonance imaging study

AU - Fernández, Guillén

AU - Weyerts, Helga

AU - Schrader-Bölsche, Michael

AU - Tendolkar, Indira

AU - Smid, Henderikus G O M

AU - Tempelmann, Claus

AU - Hinrichs, Hermann

AU - Scheich, Henning

AU - Elger, Christian E.

AU - Mangun, George R

AU - Heinze, Hans Jochen

PY - 1998/3/1

Y1 - 1998/3/1

N2 - The medial temporal lobe (MTL) is essential for episodic memory encoding, as evidenced by memory deficits in patients with MTL damage. However, previous functional neuroimaging studies have either failed to show MTL activation during encoding or they did not differentiate between two MTL related processes: novelty assessment and episodic memory encoding. Furthermore, there is evidence that the MTL can be subdivided into subcomponents serving different memory processes, but the extent of this functional subdivision remains unknown. The aim of the present functional magnetic resonance imaging (fMRI) study was to investigate the role of the MTL in episodic encoding and to determine whether this function might be restricted to anatomical subdivisions of the MTL. Thirteen healthy volunteers performed a word list learning paradigm with free recall after distraction. Functional images acquired during encoding were analyzed separately for each participant by a voxel-wise correlation (Kendall's tau) between the time series of the T2*- signal intensity and the number of subsequently recalled words encoded during each particular scan. Of the 13 participants, 11 showed voxel clusters with statistically significant, positive correlations in the posterior part of the hippocampus. Across participants, an ANOVA on the number of voxels with significant, positive correlations within individually defined volumes of interest confirmed a statistically significant difference in activation for anterior versus posterior regions of the hippocampus. However, no differences between left and right hippocampal activation were revealed. Thus, these findings demonstrate that successful encoding into episodic memory engages neural circuits in the posterior part of the hippocampus.

AB - The medial temporal lobe (MTL) is essential for episodic memory encoding, as evidenced by memory deficits in patients with MTL damage. However, previous functional neuroimaging studies have either failed to show MTL activation during encoding or they did not differentiate between two MTL related processes: novelty assessment and episodic memory encoding. Furthermore, there is evidence that the MTL can be subdivided into subcomponents serving different memory processes, but the extent of this functional subdivision remains unknown. The aim of the present functional magnetic resonance imaging (fMRI) study was to investigate the role of the MTL in episodic encoding and to determine whether this function might be restricted to anatomical subdivisions of the MTL. Thirteen healthy volunteers performed a word list learning paradigm with free recall after distraction. Functional images acquired during encoding were analyzed separately for each participant by a voxel-wise correlation (Kendall's tau) between the time series of the T2*- signal intensity and the number of subsequently recalled words encoded during each particular scan. Of the 13 participants, 11 showed voxel clusters with statistically significant, positive correlations in the posterior part of the hippocampus. Across participants, an ANOVA on the number of voxels with significant, positive correlations within individually defined volumes of interest confirmed a statistically significant difference in activation for anterior versus posterior regions of the hippocampus. However, no differences between left and right hippocampal activation were revealed. Thus, these findings demonstrate that successful encoding into episodic memory engages neural circuits in the posterior part of the hippocampus.

KW - Alzheimer's disease

KW - Declarative memory

KW - Encoding

KW - Episodic memory

KW - fMRI

KW - Functional neuroimaging

KW - Hippocampus

KW - Medial temporal lobe

KW - Memory formation

KW - Parametrical analysis

UR - http://www.scopus.com/inward/record.url?scp=2542508993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542508993&partnerID=8YFLogxK

M3 - Article

VL - 18

SP - 1841

EP - 1847

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 5

ER -