Successful treatment of erythromelalgia with intrathecal hydromorphone and clonidine

Stephen M Macres, Steven Richeimer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: The objective of this study was to determine if intractable pain from erythromelalgia could be successfully treated with intrathecal hydromorphone and clonidine. Design: A single case of pain from erythromelalgia refractory to multiple treatment modalities was examined and treated. Setting: The setting is an outpatient pain clinic at a major university teaching hospital. Patient: Our patient is an 82-year-old woman with hypertension and peripheral vascular disease. Intervention: Intrathecal opioid and an α2-agonist were administered. Outcome Measures: Outcome was determined by means of patient self-report during office follow-up visits. Results and Conclusions: Administration of intrathecal opioid and an α2-agonist can be effective in the treatment of the pain of erythromelalgia and offers an alternative pain treatment modality for patients with unremitting pain refractory to more conservative therapy.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalClinical Journal of Pain
Issue number4
StatePublished - 2000


  • Clonidine
  • Erythromelalgia
  • Intrathecal opioids

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology


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