Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog

S. Yaemsiri, Jane E Sykes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 5-year-old male castrated Lhasa Apso cross was evaluated for a 1-month history of inappetence, lethargy, gagging, and progressive right thoracic limb lameness. Synovial fluid analysis revealed nonseptic suppurative inflammation, and a diagnosis of immune-mediated polyarthritis (IMPA) was made. After 3 months of treatment with prednisone and later cyclosporine, the dog developed multiple firm cutaneous and subcutaneous masses and a focal mass within the jejunum. Cultures of blood, urine, skin lesions, and the jejunal mass identified Nocardia veterana by matrix-absorption laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and allowed for earlier identification of the organism compared to more traditional secA1 gene sequencing. Immunosuppressive drug treatment was discontinued, and the dog was treated for 3 months by administration of trimethoprim-sulfamethoxazole (TMS). No recurrence of clinical signs was reported 1 year later. This case report highlights the clinical utility of MALDI-TOF MS, particularly for the rapid identification of slow-growing, fastidious organisms.

Original languageEnglish (US)
Pages (from-to)418-422
Number of pages5
JournalJournal of Veterinary Internal Medicine
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Nocardia veterana
Nocardia Infections
Nocardia
Mass Spectrometry
Lasers
Gagging
Dogs
desorption
Lethargy
Skin
ionization
lasers
dogs
Synovial Fluid
Sulfamethoxazole Drug Combination Trimethoprim
Jejunum
Immunosuppressive Agents
Prednisone
mass spectrometry
Cyclosporine

Keywords

  • Actinomycetales
  • Antimicrobial treatment
  • Bacteremia
  • Immunosuppression
  • MALDI-TOF MS

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog. / Yaemsiri, S.; Sykes, Jane E.

In: Journal of Veterinary Internal Medicine, Vol. 32, No. 1, 01.01.2018, p. 418-422.

Research output: Contribution to journalArticle

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