Successful treatment for graft-versus-host disease after pancreas transplantation

Jei Wen Chang, Junichiro Sageshima, Gaetano Ciancio, Adela Mattiazzi, Linda Chen, Hsin Lin Tsai, Phillip Ruiz, George W. Burke

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Graft-versus-host disease (GVHD) after pancreas transplantation is a rare but serious complication: All previously reported cases were fatal. We herein report three cases of GVHD after pancreas transplantation with favorable outcomes. Patients with a history of kidney (and pancreas) transplantation subsequently received a pancreas (and kidney) transplantation (i.e., pancreas retransplantation or pancreas after kidney transplantation) and developed acute GVHD. All of them responded to increased immunosuppression (e.g., steroid bolus, antithymocyte globulin) and retained normal graft function. Because the clinical manifestations are non-specific, vigilance is necessary to make an accurate diagnosis. We underscored the importance of a biopsy of involved organs and the clinicopathologic correlation in the early diagnosis of GVHD. Augmented immunosuppression to prevent progression from a self-limited disease to life-threatening pancytopenia or sepsis may be most critical to improve outcome.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalClinical Transplantation
Volume28
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Keywords

  • Graft-versus-host disease
  • Pancreas transplantation
  • Treatment

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Chang, J. W., Sageshima, J., Ciancio, G., Mattiazzi, A., Chen, L., Tsai, H. L., Ruiz, P., & Burke, G. W. (2014). Successful treatment for graft-versus-host disease after pancreas transplantation. Clinical Transplantation, 28(2), 217-222. https://doi.org/10.1111/ctr.12300