Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Krystle L. Reagan, Stanley L Marks, Patricia Pesavento, Ann Della Maggiore, Bing Y. Zhu, Amy M. Grooters

Research output: Contribution to journalArticle

Abstract

Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti-inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible.

Original languageEnglish (US)
JournalJournal of Veterinary Internal Medicine
DOIs
StatePublished - Jan 1 2019

Fingerprint

terbinafine
Pythiosis
prednisone
Prednisone
Dogs
resection
adrenal cortex hormones
dogs
Adrenal Cortex Hormones
itraconazole
medical treatment
dog diseases
Dog Diseases
lesions (animal)
Itraconazole
Therapeutics
Clinical Protocols
Anti-Inflammatory Agents
dosage

Keywords

  • antifungal
  • colitis
  • oomycete
  • Pythium insidiosum

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone. / Reagan, Krystle L.; Marks, Stanley L; Pesavento, Patricia; Della Maggiore, Ann; Zhu, Bing Y.; Grooters, Amy M.

In: Journal of Veterinary Internal Medicine, 01.01.2019.

Research output: Contribution to journalArticle

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