Success of a steroid-minimization immunosuppression protocol for renal transplantation in the presence of donor-specific antibodies

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2 Citations (Scopus)

Abstract

Steroid-minimization regimens have gained tremendous popularity for renal Tx in the recent past since they are associated with lower metabolic complications and other adverse effects related to long-term steroid exposure. Most such protocols have been restricted to low-risk recipients due to the concern for acute rejection with steroid-minimization. Herein, we report our experience in managing a child who received a positive flow cytometry cross-match living donor kidney transplant with low titer DSA and was successfully managed using a steroid-minimization drug regimen. The purpose of our report is to make pediatric transplant care providers aware of the feasibility of using a steroid-minimization immunosuppression regimen even in children who have traditionally been perceived to be at higher risk for immunologic complications, allowing successful avoidance of steroid toxicity.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalPediatric Transplantation
Volume13
Issue number5
DOIs
StatePublished - Aug 2009

Fingerprint

Kidney Transplantation
Immunosuppression
Steroids
Tissue Donors
Antibodies
Transplants
Kidney
Living Donors
Flow Cytometry
Pediatrics
Pharmaceutical Preparations

Keywords

  • Corticosteroids
  • Donor-specific antibody
  • Kidney
  • Minimization
  • Pediatric
  • Positive cross-match
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

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abstract = "Steroid-minimization regimens have gained tremendous popularity for renal Tx in the recent past since they are associated with lower metabolic complications and other adverse effects related to long-term steroid exposure. Most such protocols have been restricted to low-risk recipients due to the concern for acute rejection with steroid-minimization. Herein, we report our experience in managing a child who received a positive flow cytometry cross-match living donor kidney transplant with low titer DSA and was successfully managed using a steroid-minimization drug regimen. The purpose of our report is to make pediatric transplant care providers aware of the feasibility of using a steroid-minimization immunosuppression regimen even in children who have traditionally been perceived to be at higher risk for immunologic complications, allowing successful avoidance of steroid toxicity.",
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