Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions

Lee A. Shapiro, Kwan Ng, Qun Yong Zhou, Charles E. Ribak

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Neurogenesis persists in several regions of the adult mammalian brain. Although the hippocampus and olfactory bulb are most commonly studied in the context of adult neurogenesis, there is an increasing body of evidence in support of neurogenesis occurring outside of these two regions. The current study expands on previous data by showing newborn neurons with a mature phenotype are located in several olfactory and limbic structures outside of the hippocampus and olfactory bulb, where we previously described doublecortin/bromodeoxyuridine immature neurons. Notably, newborn neurons with a mature neuronal phenotype are found in the olfactory tubercles, anterior olfactory nuclei, tenia tecta, islands of Calleja, amygdala, and lateral entorhinal cortex. The appearance of newborn neurons with a mature phenotype in these regions suggests that these structures are destinations, and that newborn neurons are not simply passing through these structures. In light of the increasing body of evidence for neurogenesis in these and other olfactory, limbic, and striatal structures, we hypothesize that brain regions displaying adult neurogenesis are functionally linked.

Original languageEnglish (US)
Pages (from-to)74-80
Number of pages7
JournalEpilepsy and Behavior
Volume14
Issue number1 SUPPL. 1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Fingerprint

Lateral Ventricles
Neurogenesis
Prosencephalon
Neurons
Olfactory Bulb
Phenotype
Hippocampus
Islands of Calleja
Taenia
Corpus Striatum
Entorhinal Cortex
Brain
Bromodeoxyuridine
Amygdala

Keywords

  • Adult neurogenesis
  • Bromodeoxyuridine
  • Doublecortin
  • Lesions
  • NeuN
  • Rostral migratory stream

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. / Shapiro, Lee A.; Ng, Kwan; Zhou, Qun Yong; Ribak, Charles E.

In: Epilepsy and Behavior, Vol. 14, No. 1 SUPPL. 1, 01.01.2009, p. 74-80.

Research output: Contribution to journalArticle

Shapiro, Lee A. ; Ng, Kwan ; Zhou, Qun Yong ; Ribak, Charles E. / Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. In: Epilepsy and Behavior. 2009 ; Vol. 14, No. 1 SUPPL. 1. pp. 74-80.
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