Subunit composition and novel localization of K+ channels in spinal cord

Matthew N. Rasband, James Trimmer

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Axonal K+ channels involved in normal spinal cord function are candidate targets for therapeutics, which improve sensorimotor function in spinal cord injury. To this end, we have investigated the expression, localization, and coassociation of Kv1 α and β subunits in human, rat, and bovine spinal cord. We find that Kv1.1, Kv1.2, and Kvβ2 form heteromultimeric complexes at juxtaparanodal zones in myelinated fibers. However, these same complexes are also present in paranodal regions of some spinal cord axons, and staining with antibodies against Caspr, a component of the paranodal axoglial junction, overlaps with these paranodal K+ channels. This latter observation suggests a unique role for these channels in normal spinal cord function and may provide an explanation for the sensitivity of spinal cord to K+ channel blockers. Moreover, the conservation of these characteristics between human, rat, and bovine nodes of Ranvier suggests an essential role for this defined channel complex in spinal cord function. (C) 2001 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)166-176
Number of pages11
JournalJournal of Comparative Neurology
Volume429
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Caspr
  • Kv1 K+ channels
  • Myelin
  • Na+ channels
  • Node of Ranvier
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

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