Subthalamic nucleus activation occurs early during stopping and is associated with trait impulsivity

Jong H. Yoon, Edward Dong Bo Cui, Michael J. Minzenberg, Cameron S Carter

Research output: Contribution to journalArticle

Abstract

The subthalamic nucleus (STN) is thought to be a central regulator of behavioral inhibition, which is thought to be a major determinant of impulsivity. Thus, it would be reasonable to hypothesize that STN function is related to impulsivity. However, it has been difficult to test this hypothesis because of the challenges in noninvasively and accurately measuring this structure's signal in humans. We utilized a novel approach for STN signal localization that entails identifying this structure directly on fMRI images for each individual participant in native space. Using this approach, we measured STN responses during the stop signal task in a sample of healthy adult participants. We confirmed that the STN exhibited selective activation during “Stop” trials. Furthermore, the magnitude of STN activation during successful Stop trials inversely correlated with individual differences in trait impulsivity as measured by a personality inventory. Time course analysis revealed that early STN activation differentiated successful from unsuccessful Stop trials, and individual differences in the magnitude of STN activation inversely correlated with stop signal RT, an estimate of time required to stop. These results are consistent with the STN playing a central role in inhibition and related behavioral proclivities, with implications for both normal range function and clinical syndromes of inhibitory dyscontrol. Moreover, the methods utilized in this study for measuring STN fMRI signal in humans may be gainfully applied in future studies to further our understanding of the role of the STN in regulating behavior and neuropsychiatric conditions.

Original languageEnglish (US)
Pages (from-to)510-521
Number of pages12
JournalJournal of Cognitive Neuroscience
Volume31
Issue number4
DOIs
StatePublished - Jan 1 2018

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Subthalamic Nucleus
Impulsive Behavior
Individuality
Magnetic Resonance Imaging
Personality Inventory
Healthy Volunteers
Reference Values

ASJC Scopus subject areas

  • Cognitive Neuroscience

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Subthalamic nucleus activation occurs early during stopping and is associated with trait impulsivity. / Yoon, Jong H.; Cui, Edward Dong Bo; Minzenberg, Michael J.; Carter, Cameron S.

In: Journal of Cognitive Neuroscience, Vol. 31, No. 4, 01.01.2018, p. 510-521.

Research output: Contribution to journalArticle

Yoon, Jong H. ; Cui, Edward Dong Bo ; Minzenberg, Michael J. ; Carter, Cameron S. / Subthalamic nucleus activation occurs early during stopping and is associated with trait impulsivity. In: Journal of Cognitive Neuroscience. 2018 ; Vol. 31, No. 4. pp. 510-521.
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