Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon; Yunpeng Liu; Xu Li; Xuan Wang; Xi Chen; Lei Li; Peng G. Wang

doi:10.1039/c6ob00586a

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon, Yunpeng Liu, Xu Li, Xuan Wang, Xi Chen, Lei Li, Peng G. Wang

Chemistry

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

Original language	English (US)
Pages (from-to)	4027-4031
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1039/c6ob00586a
State	Published - 2016

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ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry

Cite this

Calderon, A. D., Liu, Y., Li, X., Wang, X., Chen, X., Li, L., & Wang, P. G. (2016). Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans. Organic and Biomolecular Chemistry, 14(17), 4027-4031. https://doi.org/10.1039/c6ob00586a

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10.1039/c6ob00586a