Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon; Yunpeng Liu; Xu Li; Xuan Wang; Xi Chen; Lei Li; Peng G. Wang

doi:10.1039/c6ob00586a

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon, Yunpeng Liu, Xu Li, Xuan Wang, Xi Chen, Lei Li, Peng G. Wang

Chemistry

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

Original language	English (US)
Pages (from-to)	4027-4031
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1039/c6ob00586a
State	Published - 2016

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry

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abstract = "Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.",

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T2 - N -glycans

AU - Calderon, Angie D.

AU - Liu, Yunpeng

AU - Li, Xu

AU - Wang, Xuan

AU - Chen, Xi

AU - Li, Lei

AU - Wang, Peng G.

PY - 2016

Y1 - 2016

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Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Abstract

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