Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon, Yunpeng Liu, Xu Li, Xuan Wang, Xi Chen, Lei Li, Peng G. Wang

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

Original languageEnglish (US)
Pages (from-to)4027-4031
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number17
DOIs
StatePublished - 2016

    Fingerprint

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this