Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon; Yunpeng Liu; Xu Li; Xuan Wang; Xi Chen; Lei Li; Peng G. Wang

doi:10.1039/c6ob00586a

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon, Yunpeng Liu, Xu Li, Xuan Wang, Xi Chen, Lei Li, Peng G. Wang

Chemistry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

Original language	English (US)
Pages (from-to)	4027-4031
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1039/c6ob00586a
State	Published - 2016

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry

Access to Document

10.1039/c6ob00586a

Cite this

@article{1ce6f81f74524f749e5a132c6f18a21f,

title = "Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans",

abstract = "Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.",

author = "Calderon, {Angie D.} and Yunpeng Liu and Xu Li and Xuan Wang and Xi Chen and Lei Li and Wang, {Peng G.}",

year = "2016",

doi = "10.1039/c6ob00586a",

language = "English (US)",

volume = "14",

pages = "4027--4031",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "17",

}

TY - JOUR

T1 - Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric

T2 - N -glycans

AU - Calderon, Angie D.

AU - Liu, Yunpeng

AU - Li, Xu

AU - Wang, Xuan

AU - Chen, Xi

AU - Li, Lei

AU - Wang, Peng G.

PY - 2016

Y1 - 2016

N2 - Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

AB - Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

UR - http://www.scopus.com/inward/record.url?scp=84973351864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973351864&partnerID=8YFLogxK

U2 - 10.1039/c6ob00586a

DO - 10.1039/c6ob00586a

M3 - Article

C2 - 27080952

AN - SCOPUS:84973351864

VL - 14

SP - 4027

EP - 4031

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 17

ER -

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this