Abstract
Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4027-4031 |
| Number of pages | 5 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 14 |
| Issue number | 17 |
| DOIs | |
| State | Published - 2016 |
Fingerprint
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Biochemistry
Cite this
Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric : N -glycans. / Calderon, Angie D.; Liu, Yunpeng; Li, Xu; Wang, Xuan; Chen, Xi; Li, Lei; Wang, Peng G.
In: Organic and Biomolecular Chemistry, Vol. 14, No. 17, 2016, p. 4027-4031.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric
T2 - N -glycans
AU - Calderon, Angie D.
AU - Liu, Yunpeng
AU - Li, Xu
AU - Wang, Xuan
AU - Chen, Xi
AU - Li, Lei
AU - Wang, Peng G.
PY - 2016
Y1 - 2016
N2 - Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.
AB - Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.
UR - http://www.scopus.com/inward/record.url?scp=84973351864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973351864&partnerID=8YFLogxK
U2 - 10.1039/c6ob00586a
DO - 10.1039/c6ob00586a
M3 - Article
C2 - 27080952
AN - SCOPUS:84973351864
VL - 14
SP - 4027
EP - 4031
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 17
ER -