Abstract
Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4027-4031 |
| Number of pages | 5 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 14 |
| Issue number | 17 |
| DOIs | |
| State | Published - 2016 |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Biochemistry
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Cite this
Calderon, A. D., Liu, Y., Li, X., Wang, X., Chen, X., Li, L., & Wang, P. G. (2016). Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans. Organic and Biomolecular Chemistry, 14(17), 4027-4031. https://doi.org/10.1039/c6ob00586a