Abstract
Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.
Original language | English (US) |
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Pages (from-to) | 4027-4031 |
Number of pages | 5 |
Journal | Organic and Biomolecular Chemistry |
Volume | 14 |
Issue number | 17 |
DOIs | |
State | Published - 2016 |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Biochemistry