Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric: N -glycans

Angie D. Calderon, Yunpeng Liu, Xu Li, Xuan Wang, Xi Chen, Lei Li, Peng G. Wang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

Original languageEnglish (US)
Pages (from-to)4027-4031
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number17
DOIs
StatePublished - 2016

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Mannose
Substrate Specificity
Polysaccharides
requirements
Substrates
synthesis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric : N -glycans. / Calderon, Angie D.; Liu, Yunpeng; Li, Xu; Wang, Xuan; Chen, Xi; Li, Lei; Wang, Peng G.

In: Organic and Biomolecular Chemistry, Vol. 14, No. 17, 2016, p. 4027-4031.

Research output: Contribution to journalArticle

Calderon, Angie D. ; Liu, Yunpeng ; Li, Xu ; Wang, Xuan ; Chen, Xi ; Li, Lei ; Wang, Peng G. / Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric : N -glycans. In: Organic and Biomolecular Chemistry. 2016 ; Vol. 14, No. 17. pp. 4027-4031.
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