Substrate specificity of aromatic-L-amino acid decarboxylase

Talmage R. Bosin, Alan R Buckpitt, Roger P. Maickel

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The benzo[b]thiophene and l-methylindole analogs of tryptophan have been tested for their ability to act as substrates for aromatic-L-amino acid decarboxylase in vitro. Neither of the analogs showed detectable decarboxylation under conditions that produced significant rates of decarboxylation of tryptophan. In addition, both analogs inhibited the decarboxylation of tryptophan and phenylalanine by the in vitro system.

Original languageEnglish (US)
Pages (from-to)899-908
Number of pages10
JournalLife Sciences
Volume14
Issue number5
DOIs
StatePublished - Mar 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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