Subgroup of ADNI normal controls characterized by atrophy and cognitive decline associated with vascular damage

Jasmine Nettiksimmons, Laurel A Beckett, Christopher Schwarz, Owen Carmichael, Evan Fletcher, Charles DeCarli

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Previous work examining Alzheimer's Disease Neuroimaging Initiative (ADNI) normal controls using cluster analysis identified a subgroup characterized by substantial brain atrophy and white matter hyperintensities (WMH). We hypothesized that these effects could be related to vascular damage. Fifty-three individuals in the suspected vascular cluster (Normal 2) were compared with 31 individuals from the cluster characterized as healthy/typical (Normal 1) on a variety of outcomes, including magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers, vascular risk factors and outcomes, cognitive trajectory, and medications for vascular conditions. Normal 2 was significantly older but did not differ on ApoE4+prevalence. Normal 2 differed significantly from Normal 1 on all MRI measures but not on Amyloid-Beta1-42 or total tau protein. Normal 2 had significantly higher body mass index (BMI), Hachinksi score, and creatinine levels, and took significantly more medications for vascular conditions. Normal 2 had marginally significantly higher triglycerides and blood glucose. Normal 2 had a worse cognitive trajectory on the Rey's Auditory Verbal Learning Test (RAVLT) 30-min delay test and the Functional Activity Questionnaire (FAQ). Cerebral atrophy associated with multiple vascular risks is common among cognitively normal individuals, forming a distinct subgroup with significantly increased cognitive decline. Further studies are needed to determine the clinical impact of these findings.

Original languageEnglish (US)
Pages (from-to)191-201
Number of pages11
JournalPsychology and Aging
Volume28
Issue number1
DOIs
StatePublished - 2013

Keywords

  • ADNI
  • Biomarkers
  • Cluster
  • Cognitive decline
  • Vascular

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Social Psychology

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