Subgenual anterior cingulate activation to valenced emotional stimuli in major depression

Ian H. Gotlib, Heidi Sivers, J. D E Gabrieli, Susan Whitfield-Gabrieli, Philip R Goldin, Kelly L. Minor, Turhan Canli

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Major depression has been associated with anomalous activation in the subgenual anterior cingulate cortex, but its response to emotional stimuli is poorly understood. The primary goal of this study was to compare levels of activation in the subgenual anterior cingulate cortex of diagnosed depressed and nondepressed participants in response to happy and sad facial expressions of affect. Whereas cognitive theories of depression predict increased activation to negative stimuli, depressed participants were found to exhibit increased activation to both types of stimuli in the subgenual anterior cingulate cortex. Importantly, the loci were in different regions of the subgenual anterior cingulate cortex, suggesting that there is functional specialization in the processing of negatively and positively valenced stimuli.

Original languageEnglish (US)
Pages (from-to)1731-1734
Number of pages4
JournalNeuroReport
Volume16
Issue number16
DOIs
StatePublished - Nov 7 2005
Externally publishedYes

Keywords

  • Affective neuroscience
  • Emotion
  • Functional magnetic resonance imaging
  • Information processing
  • Neurophysiology
  • Unipolar depression

ASJC Scopus subject areas

  • Neuroscience(all)

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