Abstract
Background and Purpose: Patients with lupus anticoagulants do not typically have a bleeding tendency. However, a few reports of hemorrhage in patients with lupus anticoagulants in the absence of known risk factors for bleeding have been published, raising the question of an etiologic connection between lupus anticoagulants and certain types of hemorrhage. The presentation of three patients with subdural hematoma and lupus anticoagulants within only 1 year at our institutions and the report of two such patients in the literature led us to conduct a retrospective study to determine whether patients with lupus anticoagulants may have an increased risk for the development of subdural hematoma. Case Descriptions: All patients with a discharge diagnosis of nontraumatic subdural hematoma and lupus anticoagulant at three medical institutions between 1985 and 1996 were identified, and their medical histories and laboratory evaluations were reviewed. Of 733 patients with a discharge diagnosis of nontraumatic subdural hematoma, 5 were diagnosed as having a lupus anticoagulant (0.7%). All had known risk factors for the development of subdural hematoma: thrombocytopenia, hypoprothrombinemia, intracerebral venous hemorrhage, warfarin therapy, and advanced age with a history of a fall. Conclusions: This study suggests that presence of a lupus anticoagulant by itself is not associated with an increased incidence of nontraumatic subdural hematoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 646-648 |
| Number of pages | 3 |
| Journal | Stroke |
| Volume | 28 |
| Issue number | 3 |
| State | Published - Mar 1997 |
| Externally published | Yes |
Fingerprint
Keywords
- anticoagulants
- antiphospholipid antibodies
- hematoma
- lupus anticoagulant
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Neuroscience(all)
Cite this
Subdural hematoma and lupus anticoagulants. / Moll, Stephan; McCloud, Michael; Ortel, Thomas L.
In: Stroke, Vol. 28, No. 3, 03.1997, p. 646-648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subdural hematoma and lupus anticoagulants
AU - Moll, Stephan
AU - McCloud, Michael
AU - Ortel, Thomas L.
PY - 1997/3
Y1 - 1997/3
N2 - Background and Purpose: Patients with lupus anticoagulants do not typically have a bleeding tendency. However, a few reports of hemorrhage in patients with lupus anticoagulants in the absence of known risk factors for bleeding have been published, raising the question of an etiologic connection between lupus anticoagulants and certain types of hemorrhage. The presentation of three patients with subdural hematoma and lupus anticoagulants within only 1 year at our institutions and the report of two such patients in the literature led us to conduct a retrospective study to determine whether patients with lupus anticoagulants may have an increased risk for the development of subdural hematoma. Case Descriptions: All patients with a discharge diagnosis of nontraumatic subdural hematoma and lupus anticoagulant at three medical institutions between 1985 and 1996 were identified, and their medical histories and laboratory evaluations were reviewed. Of 733 patients with a discharge diagnosis of nontraumatic subdural hematoma, 5 were diagnosed as having a lupus anticoagulant (0.7%). All had known risk factors for the development of subdural hematoma: thrombocytopenia, hypoprothrombinemia, intracerebral venous hemorrhage, warfarin therapy, and advanced age with a history of a fall. Conclusions: This study suggests that presence of a lupus anticoagulant by itself is not associated with an increased incidence of nontraumatic subdural hematoma.
AB - Background and Purpose: Patients with lupus anticoagulants do not typically have a bleeding tendency. However, a few reports of hemorrhage in patients with lupus anticoagulants in the absence of known risk factors for bleeding have been published, raising the question of an etiologic connection between lupus anticoagulants and certain types of hemorrhage. The presentation of three patients with subdural hematoma and lupus anticoagulants within only 1 year at our institutions and the report of two such patients in the literature led us to conduct a retrospective study to determine whether patients with lupus anticoagulants may have an increased risk for the development of subdural hematoma. Case Descriptions: All patients with a discharge diagnosis of nontraumatic subdural hematoma and lupus anticoagulant at three medical institutions between 1985 and 1996 were identified, and their medical histories and laboratory evaluations were reviewed. Of 733 patients with a discharge diagnosis of nontraumatic subdural hematoma, 5 were diagnosed as having a lupus anticoagulant (0.7%). All had known risk factors for the development of subdural hematoma: thrombocytopenia, hypoprothrombinemia, intracerebral venous hemorrhage, warfarin therapy, and advanced age with a history of a fall. Conclusions: This study suggests that presence of a lupus anticoagulant by itself is not associated with an increased incidence of nontraumatic subdural hematoma.
KW - anticoagulants
KW - antiphospholipid antibodies
KW - hematoma
KW - lupus anticoagulant
UR - http://www.scopus.com/inward/record.url?scp=0030890455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030890455&partnerID=8YFLogxK
M3 - Article
C2 - 9056625
AN - SCOPUS:0030890455
VL - 28
SP - 646
EP - 648
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 3
ER -